THeo NICHOLS -> THNICHOLS -> THNICKELS
... no?
So... it is kind of a mixed bag in terms of if they actually make fights safer.
Also throwing a bare knuckle punch against someone's head has a large likelihood of the puncher breaking multiple bones, though depending on the outcome that may be preferable to other alternatives.
In general: use your sneakers; if necessary, push opponents away with with your palms and tightly held fingers.
This is indeed the 1st, 2nd, and frequently 3rd, suggested strategy from any good self defense teacher!