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Posted by ortegaygasset 6 days ago

The first non-opoid painkiller(www.worksinprogress.news)
246 points | 226 commentspage 3
lloydatkinson 6 days ago|
Paracetamol etc is an opiod?
hinkley 6 days ago||
No. Not even the 100th.

Wikipedia:

> At least 100 distinct phytocannabinoids have been isolated from cannabis, although only four (i.e., THCA, CBDA, CBCA and their common precursor CBGA) have been demonstrated to have a biogenetic origin.[6] It was reported in 2020 that phytocannabinoids can be found in other plants such as rhododendron, licorice and liverwort,[7] and earlier in Echinacea.

Cannibinoid receptors are separate from opioid receptors.

StochasticLi 6 days ago|
They give me massive anxiety.
hinkley 6 days ago||
Well then I hope the 111th non opioid painkiller works for you. I know people in chronic pain (my body isn’t exactly a picnic) and so far none of them have gotten hooked on oxy but it’s always looming.
StochasticLi 4 days ago||
Please name them.
cwmoore 6 days ago||
decaf anyone?
bheadmaster 6 days ago||
[flagged]
usagisushi 6 days ago|
And then the story begins when the creator announces that everyone who took it will die within a month...
reliablereason 6 days ago|
According to our psychological theories any sufficiently fast acting and strong painkiller will be addictive as long as it removes or reduces any type of pain.

Seams strange if this one truly will not have "drug abuse" connected to it.

dwroberts 6 days ago||
The impression I got from Wikipedia reading about this (suzetrigine) is that it’s not addictive because it acts on peripheral nerves and not directly in your brain
reliablereason 6 days ago||
Given how scared people are of "addiction" the seller certainly would like that narrative and it might make sense from a withdrawal perspective. Which in turn has an effect on how addictive a drug is to a very large degree.
Akasazh 5 days ago|||
Yeah, the lack of addictiveness was one used to promote the spiffy new drug heroine over the addictive morphine.
tossandthrow 6 days ago||
I am very curious about these theories, can you refer them?
reliablereason 6 days ago||
Operant conditioning https://en.wikipedia.org/wiki/Operant_conditioning

There are also lots of studies indicating that the speed of action of a drug is important for addiction. Which essentially boils down to the fact that the brain (beeing effected by operant conditioning) needs a drug response that is sufficiently noticeable to be connected to the action of taking the drug.