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Posted by fzliu 6/27/2025

Biomolecular shifts occur in our 40s and 60s (2024)(med.stanford.edu)
171 points | 130 commentspage 2
Nopoint2 6/27/2025|
I still stand by my claim that the most common cause of death is chronic iron poisoning, and living past 100 was a regular occurence in the bronze age.

The best explanation again seems that all the modern nutrition is nonsense fed by some double agent to the allies in WW2, (iron, and the toxicity of heavy metals) based supposedly on some secret concentration camp experiments, and nobody is allowed to question it in order to "not let their sacrifice go in vain" or some such bullshit.

ohthehugemanate 6/27/2025|
Particularly interesting is that when they split the dataset by sex, the transitions were present and at a similar magnitude in both sexes. We make much in western culture of the (peri-)menopausal change in women. I read this as an indicator that at least significant parts of the transition in this age range for men - acknowledged for a long time now - are just as big as menopause.

I don't remember noticing that the last time this study came around, but then again, I am in my mid 40s. :)

squidbeak 6/27/2025||
> I read this as an indicator that at least significant parts of the transition in this age range for men - acknowledged for a long time now - are just as big as menopause

Men emerge from it with their fertility intact.

darkwater 6/27/2025||
Sorry but your post as strong #notallmen vibes. The article itself mentions that part of those changes might just be explained by lifestyle changes at 40s. I quote:

> It's possible some of these changes could be tied to lifestyle or behavioral factors that cluster at these age groups, rather than being driven by biological factors, Snyder said.

Changes in women metabolism due to menopause are pretty known and proved, and men don't experience it. I'm a mid-40s male as well.