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Posted by Anon84 3 days ago

Schizophrenia is the price we pay for minds poised near the edge of a cliff(www.psychiatrymargins.com)
255 points | 393 commentspage 3
PaulHoule 3 days ago|
Why does no-one dare say "schizotypy?"

https://en.wikipedia.org/wiki/Schizotypy

gfody 3 days ago||
many people hear voices and experience symptoms of schizophrenia while managing to keep their cool and thrive amongst the nerts. hearing-voices.org is a support network for such people
crawfordcomeaux 3 days ago||
It's dangerous to existing systems for people to become aware they're capable of creating/conjuring/channeling useful new voices in the mind to help learn different things. People get burned at the stake for that.
bad_haircut72 3 days ago|||
I've never ever had any symptoms of schizophrenia but the idea of trying to consciously encourage myself hearing voices is terrifying, Im sure I could send myself truly insane with probably not much effort.
WarOnPrivacy 3 days ago|||
> the idea of trying to consciously encourage myself hearing voices is terrifying,

This is not unreasonable.

It could be less awful if the voices were positive and not harsh and negative. Schizophrenics outside the US were found to have a more benign relationship with their voices.

    The striking difference was that while many of the African
    and Indian subjects registered predominantly positive experiences
    with their voices, not one American did. Rather, the U.S. subjects
    were more likely to report experiences as violent and hateful – and
    evidence of a sick condition. 
ref: https://news.stanford.edu/stories/2014/07/voices-culture-luh...
crawfordcomeaux 2 days ago||||
I once accidentally came up with another conscious voice in my head & we decided to govern through the 12 traditions of Codependents Anonymous. She also had specific qualities I'd chosen 3 weeks prior as qualities I chose to believe I could come to embody, so that was an interesting pointer to what's possible.

And as others have pointed out, it really depends what kind of programming you're carrying around. Feeling terrified of something isn't the issue...it's how you've trained to respond to terror that matters. If you lash out or avoid, yeah....don't cultivate multiple voices. If, instead, you're choosing to purge the addiction to violence & domination fairly rooted in American imperial colonial indoctrination, it's really quite something. I'm now working on bringing in 16 others as a way to better connect with different parts of the population and spread this and other blackness-embracing ways.

Hearing/seeing things that aren't there has historically for the majority of humanity's time on Earth not been an issue. We can get back to living in such ways, especially since doing so can be extremely helpful.

PaulHoule 3 days ago|||
My belief about is that the core of schizotypy and schizophrenia is

https://en.wikipedia.org/wiki/Thought_disorder

as did Eugen Bleuler. I have a friend who is schizophrenic whose speech hardly makes sense and she is always calling people on the phone and carrying on nonsensical conversations. Somehow the general public is hung up on ‘hearing voices’ but I have never once heard a voice but under stress I (schizotypal) did once spend about six months under the influence of a ‘system of delusions’ yet stayed mostly functional, kept working, and managed to avoid getting in serious trouble.

I think it is quite ordinary also for people to have a dialogue with an ‘invisible friend’ or believe that they ‘talk to God’ when they pray, the auditory hallucinations of schizophrenia seem to be something like you have a thought that you don’t think is your thought but somebody else talking, notably schizophrenics often believe that somebody is putting thoughts into them or taking thoughts out of them, see

https://www.theairloom.org/mindcontrol.php

DiscourseFan 3 days ago|||
It's like gang-stalking--its not that there's something being introduced, but rather that the subject sees relations that are not objective relations (like, for instance, the relation between temperature, pressure, and state change). Typically, however (and I can't imagine a case where this didn't happen), the relations are social in character--and since social relations are subjective to the extent that all the social world is not expressly a fact, it can be difficult to differentiate between an illusion and a reality: people imagine their partners are cheating on them, whether or not its true. And there are many things we do not know about the social world around us; but, statistically speaking, nobody has ever actually been gang-stalked.
overu589 2 days ago||
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andygeorge 2 days ago||
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dang 2 days ago|||
Please don't post unsubstantive comments.
overu589 2 days ago||
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overu589 2 days ago|||
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DiscourseFan 2 days ago|||
Modern medicine.
crawfordcomeaux 2 days ago|||
Hey there! Let's be friends! Too rare are there people speaking/writing past myopic American/western views here.
uniq7 3 days ago|||
That is very interesting. Excuse me if this question is too personal, but what do you mean by "system of delusions" exactly?
ivape 3 days ago||
A constant state of needing to do continuous reality testing. The GP almost lost a grip basically.
PaulHoule 3 days ago|||
Dangerous to the autism-industrial complex and as well as the addictive stimulant industry.
WarOnPrivacy 3 days ago|||
> addictive stimulant industry.

Whom I thank every day for repairing my retention processes, just enough that lessons become learning.

astrange 2 days ago||||
Stimulants reduce addictive behaviors in ADHD patients.

https://www.additudemag.com/adhd-and-substance-abuse-stimula...

They're also less habit forming than the non-stimulant drugs; I'm taking a non-stimulant right now (Intuniv) that you can't safely quit without tapering off for weeks.

The combination is good enough that I lost my caffeine addiction. Of course that's a relatively mild one.

amanaplanacanal 3 days ago|||
Is this supposed to be some kind of diss for adhd stimulant therapy?
PaulHoule 3 days ago||
Gotta a friend who’s 52 and has all his teeth rot out 10 years ago. He goes to Wegmans every month and comes back with a pill bottle the size of a small trashcan. He says he could get nothing done without out but I don’t see him getting anything done. Wouldn’t be surprised if will fall and break his hip 20 years early.

I’ve seen plenty of those pills get diverted with outcomes like somebody stays up for 4 days and gets hospitalized so, yeah, I want to diss ADHD medication. It is clear it helps in the short term, not so clear if it helps in the long term.

WarOnPrivacy 3 days ago|||
> Gotta a friend who’s 52 and has all his teeth rot out 10 years ago.

FTR, meth mouth has no overlap with ADHD meds. I specifically looked into this, way back when.

> He goes to Wegmans every month and comes back with a pill bottle the size of a small trashcan.

If he took that many ADHD meds he'd be dead on day one. Three tabs/day is a heavy dose.

fragmede 3 days ago|||
How scientific.
PaulHoule 3 days ago||
https://pubmed.ncbi.nlm.nih.gov/35091797/
WarOnPrivacy 3 days ago||
Even that very limited study didn't link stim use to poor teeth - at all. As far as study went, this was it.

    • Stimulant ADHD medication use in adults is associated with decreased bone
     mineral in the skull and thoracic spine.

    • No other areas of axial or appendicular skeleton showed significant
    differences.

    • There was no dose-response effect between stimulant medication use and
    bone mineral density.

    • The overall effect of stimulant medications on adult
    bone health is unclear. 
ref: https://pmc.ncbi.nlm.nih.gov/articles/PMC9062265/
bryanrasmussen 2 days ago||
>The persistence of schizophrenia is an evolutionary enigma

how much schizophrenia is actually going to manifest in peak procreating years?

rozab 2 days ago||
Reproductive fitness does not end as soon as offspring are born. Maximising the likelihood of genetic continuation is a lifelong endeavor.
throw-qqqqq 2 days ago||
I have two relatives with schizophrenia. Both had onset in their mid 20s.
bryanrasmussen 2 days ago||
yeah but a sizeable part of the discussion here has been about women with menopause starting to show schizophrenic behaviors. So that might be a significant amount of the schizophrenic cases in the population.
throw-qqqqq 2 days ago||
> So that might be a significant amount of the schizophrenic cases in the population

I dont think they are. Most are diagnosed in their teens or early twenties. Women slightly later than men.

Women diagnosed in their menopause are not a majority of diagnosed schizophrenics; far from.

I understood that part as merely a curiosity.

bryanrasmussen 2 days ago||
OK, I just figured if there were specific large groups of schizophrenics that manifested outside of prime procreative years that it might be a reason for it to not be such an evolutionary mystery. Of course it was unlikely this was the case as surely some of the people claiming evolutionary mystery would have thought of it and ran the data.
jonahbard 3 days ago||
I wonder if Autism would be even simpler to explain with a cliff-edged fitness function. Because there seems to be a high correlation between extremely intelligent people and people on the spectrum. Maybe the group of genes rewarded for high intelligence/creativity/quantitative ability also, by accidental design, inhibits social capacity.
mandmandam 3 days ago||
> Maybe the group of genes rewarded for high intelligence/creativity/quantitative ability also, by accidental design, inhibits social capacity.

Maybe living in a world with neurotypical people who immediately dislike you [0] 'inhibits social capacity' after years of traumatic experiences piling up.

0 - https://pmc.ncbi.nlm.nih.gov/articles/PMC8992906/

hyperhello 3 days ago|||
Is it possible that every non-typical presentation simply tells others in society to give them space enough to develop the intellect?
PaulHoule 3 days ago||
Maybe it does when you are an adult but it can make childhood a disaster.
Mistletoe 2 days ago||
> Let’s say schizophrenia is associated with a 50% loss of reproductive fitness in 1% of the population (and there is no offsetting benefit in the rest of the population), then it would take roughly 180 generations to cut the rate in half and about 560 generations to reduce it to one-tenth of its original value (Mitteroecker & Merola, 2024). We’ve had a comparable number of generations since the Neolithic era, but as far as we know, the prevalence of schizophrenia has not decreased in the manner anticipated.

What if the number we experience now IS 1/10 of what it used to be? Would explain a lot of religious talking to God in the past.

daft_pink 3 days ago||
After reading this article, I’m really curious how you would model all kinds of other reproduction reducing behaviors that have become popular in recent years and how they many generations it will take them to be squeezed out of our culture. Like say taking care of a pet instead of having a kid in Korea.
sandspar 3 days ago|
One plausible explanation is that birth and childhood have become much less dangerous. Before 1900, children with poor genes died; since 1900, children with poor genes survive and have children of their own.
rixed 2 days ago||
My understanding of high child mortality rates in the past is that it has little to do with genetics, and more to do with infectious diseases and poor hygiene.
Raphell 1 day ago||
I know someone who had a clear psychotic break and still hasn't fully recovered. The scariest part wasn't when he lost control. It was that he truly believed everything made perfect sense. The more you tried to care for him, the more he thought you were acting and trying to manipulate him.
sakoht 3 days ago||
The article suggests a possible model where the schizophrenia is an extreme linear progression. But the inability to find a culprit genes suggests something more complex. It is possible that there are is a group of genes that all have variations that confers benefit, but when those variations are all together negative effects occur. That makes the positive variants overall beneficial, and keeps them in the gene pool. This is why it is dangerous to presume that when we correlate genetic variants with disease and then presume they should go away. In fact, nearly any inherited disease that has survived may be conferring value to other individual when in proper partnership with other genetic profiles.
FollowingTheDao 2 days ago|
This is true for every population. For instance, the price of protecting many African populations from malaria is sickle cell disease.

But I think environment plays a bigger role in modern society to increase the risk of mood disorders than genetics alone.

cjbgkagh 3 days ago||
I think people should study the RCCX gene cluster and link to giftedness more, I have TNXB SNPs which results in hEDS, but C4 SNPs have a similar effect and is likely to result in Schizophrenia. There are some cross over symptoms such as dopamine dysregulation and flat affect. I think dysautonomia and auto-immune plays a big part. Our lifestyles are very different than they used to be and this could be exacerbating auto-immune issues and as we get better at treating auto-immune conditions I expect we'll get better at treating Schizophrenia.
PaulHoule 3 days ago|
Is there some puzzling chronic condition that isn’t on this list?

https://me-pedia.org/wiki/RCCX_Genetic_Module_Theory

cjbgkagh 3 days ago||
Of course there are. I'm guessing you're insinuating two things, it's highly improbable that individuals can have this many simultaneous issues, and it's impossible for medical researchers to miss such an anomaly. The Ehlers Danlos subset is shorter but still covers a huge amount of issues (https://ohtwist.com/about-eds/comorbidities).

Well there is a reason why doctors kept telling me I am a hypochondriac, but I do have a whole zoo of conditions simultaneously, and this is a pretty common state for people with hEDS and I'm on the extreme end of it. So while milder versions of it are ~2% of the population the extreme versions of it are < 1/20K.

And yeah, medical researchers are in fact in the aggregate really bad at their jobs. Look how long it took to convince surgeons to wash their hands. But a lot of the genetic stuff relies on Linear Regression for GWAS which assumes independents of SNPs, otherwise you get multicollinearity problems, this is not a safe assumption and they've confused their results as confirming their assumptions. Instead of listing everything they get wrong a much shorter list is what they get right, Dr Jessica Eccles (https://x.com/BendyBrain) does great research into Long Covid and Generalized Joint Hypermobility which should put to bed the theory that GJH is benign - still good luck trying to talk a doctor out of that train of thought.

If you find someone who has hEDS the odds are they have a very large number of those things and most of them don't even know the names of most of the conditions, just one or two that bother them the most. The RCCX / hEDS list is a distinct subset of all possible things, the list of all medical maladies is far longer. It becomes highly improbable that a set of people have the same set of maladies - doctors tend to chalk this up to social contagion but that doesn't bear out. Genetic and behavioral causes have distinct diffusion patterns.

It's confirmable with WGS which I've done and I've encouraged many others to do and it turns out that you can indeed predict with a great deal of reliability if someone has TNXB / CYP21A2 SNPs. Unfortunately it's harder to find people who have C4 since they're likely to have schizophrenia.

gavinray 2 days ago||
Do you have a list of which SNP's are related to this/are pathological?

I have an Ancestry partial genome that I've imputed to expand. Would be curious whether those SNP's are present in the data.

cjbgkagh 2 days ago||
They are listed as benign, since I find the people first then get the sequence I think that classification is incorrect.
cjbgkagh 2 days ago||
There are many TNXB SNPs and many are not rare, while I can theorize that the number and severity of the SNPs can explain a spectrum I don't have enough data to prove it. The data that I do have is highly improbable to be from random chance, but not impossible so I'm still collecting and am open to being wrong.
r33b33 2 days ago||
If you have caution and paranoia about potentially being schizophrenic, does that mean it's less likely to manifest due to extreme self-awareness? I have been diagnosed with BPD, psychosis (sometimes) and depression, but I think I'm too aware when it comes to shizhophrenia.
storus 2 days ago|
Isn't it due to synaptic pruning going wrong, a sort of off-by-one error of a gene tagging synapses for deletion?
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