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Posted by 1659447091 6 days ago

Ultrasound is ushering a new era of surgery-free cancer treatment(www.bbc.com)
278 points | 86 commentspage 2
deep_signal 11 hours ago|
It's amazing how we're turning sound waves into healing tools.
michael1999 7 hours ago||
My mother received ultrasound ablation as brain surgery to treat idiopathic tremors. It was wild.
breppp 11 hours ago||
It's a highly promising direction for many diseases, I specifically remember Alzheimer's as one

https://www.fusfoundation.org/diseases-and-conditions/

mountainriver 8 hours ago||
Also very very interesting for brain modulation!
nilslindemann 9 hours ago||
I hope for a great future of this therapy.
zzzeek 6 hours ago||
I've got a node in my thyroid that can reasonably only be removed chemically, which has risks of blowing out my whole thyroid. ultrasound treatment is now available for it, however have been going to my endocrinologist every four months for a bloodwork checkup (because I need to take thyroid-suppressing drugs until the node can be removed) and am still waiting for him to have heard about this treatment outside of my own telling him so (even though his larger medical organization, NYU, offers it, it still seems to not be routine within his practice).
BurningFrog 6 hours ago|
There has to be a way to find a practice that uses this tech?
zzzeek 5 hours ago||
absoultely but I am in no hurry and I would like it to be Very Boring and Ordinary For My Particular Condition before I go anywhere near it
fortran77 10 hours ago||
I really hope she didn't damage her (or her colleague's) hearing while doing these experiments!
sho_hn 14 hours ago||
How's progress on individualized cancer remedies based on mRNA?
michaeljx 13 hours ago|
Don't know about mRNA but individualized remedies based on CAR-T technology have been making significant strides in this area, with major commercialisation expected in the next 1-2 years
jijji 11 hours ago||
The only thing the article fails to mention is the use of more than one transducer used to focus multiple ultrasound beams to an intersection point in the body, increasing the heating power of all beams
infinet 9 hours ago|
There was a startup in Shanghai in the early 2000. Their device used multiple transducers. The probe was at least 40 cm in diameter. They did trials on uterine fibroids, among other diseases. One of the difficulties was while it looks good in theory, but the path ultrasound travels in the body is more complicated than, say x-ray or gamma ray. They expected a fine focal zone, but sometimes the focal zone was much larger than expected. This new wave of ultrasound equipment may have discovered better ways to control the sound beam.
jijji 4 hours ago||
it seems like the intesection point can be smaller than a grain of rice, and moved at 0.1mm three dimensionally [0]

[0] https://youtu.be/3Bwq2YxD9eU

infinet 2 hours ago||
This is amazing! That HIFU 20 years ago used phase array to steer beam. Don't know the size of transducer. One of the tests I heard of was on a pig leg. The damage was bigger than expected, could be in the range of few centimeters, probably due to the leg has skin, subcutaneous fat, muscle and bone. All have different sound characteristic.
verisimi 5 hours ago|
If it can target and kill cancer, how can it also be safe for foetuses?
BobaFloutist 5 hours ago||
That's like asking how if a laser can cut through steel how lamps can be safe to have indoors.
verisimi 4 hours ago||
Do you have a link or something that compares the power in both? I can't find one.

This is the summary I get from chatgpt - comparing Histotripsy and ultrasound imaging

| Property | Strongest Diagnostic / Imaging Ultrasound | Histotripsy (Therapeutic Ultrasound |

| Frequency | 2 – 10 MHz (obstetric: 2–5 MHz; high-res imaging up to 15 MHz) | 0.25 – 3 MHz (sometimes up to 6 MHz) |

| Pressure (Peak Negative) | Up to ~5–6 MPa (mechanical index limit ≈ 1.9) | 10 – 100 MPa (depending on type: intrinsic vs. boiling histotripsy) |

| Intensity (Spatial Peak, Temporal Average) | Typically < 0.1 W/cm²; upper safe limit ≈ 0.72 W/cm² (FDA/AIUM) | 100 – 10,000 W/cm² (very high peak intensities) |

| Pulse Duration | Microseconds (∼1–5 µs typical) | Microseconds to milliseconds (short bursts for mechanical disruption) |

Its kind of hard to know what this means - some of the numbers seem pretty close/crossover - but I don't think saying the difference is akin to a laser and a light.

an-honest-moose 2 hours ago||
There are 2 to 5 orders of magnitude difference in intensity. That alone is a pretty big difference.
f1shy 5 hours ago|||
You can vary the frequency, power, energy, focus... is not the SAME ultrasound.
verisimi 5 hours ago||
But surely it could cause some damage at a lower frequency, power, etc anyway?
fragmede 5 hours ago||
Shit, you figured it out. It's not! That's whats been causing all the autism! Big ultrasound has been managing to keep this under wraps for decades!