Posted by ck2 6 hours ago
I worked on a project many years ago to do RNA import into yeast mitochondria (and then hopefully reverse transcribe there). Didn't work, and a lot of the info on RNA import into the mitochondria is... suspect.
Mitochondria engineering is just actually tough. 30 years and no new protocols for getting DNA in there :(
"Hey ChatGPT, I need third ear. Make it grow in two months."
Or a wicked disease state like Huntington's that causes your DNA to slip.
Simple failures with catostrophic outcomes are much more likely than rewiring and restarting all of the developmental program across huge cell and tissue populations.
It would be more likely to grow transplant tissue exogenously. It's far safer than using the body as a test tube.
These gene editing techniques are used to fix simple (typically one cause) genetic diseases. Not reengineer live organisms "in flight".
And yet, like a startup that found product market fit with a garbage tech stack, this pile of jenga spaghetti is still going strong. Complexity doesn’t matter, people dying because they looked at a peanut doesn’t matter - ultimately this spaghetti works well enough to get humans to where we are today.
Nice list here: https://github.com/davidliwei/awesome-CRISPR
We have a lot of increasing hormone production issues in western society already, I'm not sure that fiddling with things further is a real solution here without risking a lot of damage to society as a whole.
Can you point to a reference?
this should work?
https://archive.is/https://www.nature.com/articles/d41586-02...