Posted by PaulHoule 2 days ago
Does GPL-1 also dampen those? How much does it dampen just any fixed behavior?
However, Ozempic will be generic early 2026 in Canada, and there's no way in hell I would pay 4-5x the difference (I'm guessing) for mounjaro as the benefit is relatively minor already given the half life difference (right now the price is almost the same).
I’m not diabetic, so my insurance doesn’t cover it, meaning I have to pay full price, which only went up after Eli Lilly switched from vials to pens in Canada. I genuinely hate Eli Lilly for : 1) their pricing, 2) for eliminating vials in favor of pens, and 3) for how they handled my situation. I reached out to their customer service honestly, admitting I wouldn’t qualify for a discount (even though I’d seen countless Reddit posts from people lying on the form and getting approved anyway and told them this). I reached out and requested in good faith and was flat-out denied, basically brushed off by their support team. This destroyed a lot of goodwill i had initially towards them because of better results and any future brand loyalty I might have had.
I am in a career that I really enjoy, but which requires high motivation and productivity. I don't want to lose that along with the pounds.
Almost 2 years now. I'm not religious about it and will occasionally drink the celebratory glass of bubbles or a beer (alcohol free if available) when it's hot outside.
Very interesting how it has worked.
In November of 2024, I decided to avoid alcohol as a personal experiment - no GLP-1 medications involved. I have not consumed any alcohol since.
After 3-4 months, my interest in alcohol seemed to really fall off a cliff. I joked with friends that I was going "dry in 2025", but I am now more seriously considering taking 2026 off from alcohol as well before making a decision about whether to add alcohol back into my diet.
I realize how completely dumb this question might sound.
Yes, anything from a couple of drinks a night with dinner / tv to getting blackout drunk multiple times a week, alone, with your significant other, or with friends / roommates.
In the case of people in my social circle (late 30s early 40s) it's primarily still for fun, as well as just a large amount of momentum from your teenage years, 20s, 30s, etc. For a lot of people I know, the association between drinking and good times / relaxation has been deeply engrained since high school.
I've recently taken an extended break for my health, as I'm fully aware that it takes a toll on me, but I still love grabbing some drinks whether I'm relaxing alone in the evening or going out with friends and family.
While it's certainly true that many people get into a dark place with drinking and let it spiral into a self-destructive, depressive pursuit, I don't think it's quite the rule it's made out to be.
I have a good amount of family who live idyllic, full, happy, social lives, drinking heavily multiple times a week with their friends and family into their 70s/80s until death.
But it can easily escalate into a rather unhealthy habit. And even fairly small amounts can disrupt sleep.
Does anyone else feel a slight sense of worry about this?
I was not addicted to gaming before so can’t really tell the difference there.
Guess what? That's a good thing. The anxious person I was drove me to struggle to do basic life things, struggle to do things I wanted to do, and caused me to drive away someone I loved and harm them.
Fuck that guy, I don't want to be him. I did change. I became able to try new things. I became able to accept other people without needing to impose what I considered "right" onto them. I became able to manage my stupid jealousy to stop it from hurting my relationships.
Now I can ride rollercoasters without having a panic attack. Oh what a shame I lost that guy.
The things that medications treat also cause personality changes. Significant mental or psychological problems consume parts of you, and drive your life negatively.
There's no such thing as a "true" you. You are just biological machines doing chemistry. That chemistry dictates YOU. That chemistry is literally affected by the food you eat. Drawing a line because we require you to get a chemical from someone with a special piece of paper is not reality.
Wearing the proper glasses will cause a personality change if you grew up vision impaired.
Don't deify a broken brain.
Other lies people insist on to avoid medication include "There's no silver bullet/magic pill"
Guess what? Sometimes there is! A low dose of a boring medication fixed my anxiety, as in, turned me from being a dysfunctional anxious wreck to someone who has a normal anxiety response. Even the "side effects" I experience have been positive outcomes.
Now if you do something like take anabolic steroids and it gives you roid rage? Yeah, avoid that, not because "It changed you" but because it made you demonstrably worse in a way you probably do not want
Do you know what else causes irreversible personality changes and will change who you really are?
Aging.
It's really easy to get them in the UK from a variety of online and high street pharmacies, including from well-known brands like Boots, Lloyds Pharmacy, or ASDA.
As to advertising, my perception is that it's wrapped in a "weight loss clinic" style presentation but you don't have to be on all the sites long before you get to the "buy $GLP-1" here :)
It seems it doesn't block dopamine generally, but does seem to act on dopamine spikes?
One breakthrough and then a WHOLE BUNCH OF NEW STUFF happens all at once now that this new idea or new pathway is created.
mRNA vaccines break away and now they're testing them in everything. GLP-1 showing signs of use in obesity and now it's being tested for a whole gamut of other things. All very exciting!
99% of promising mice studies does not result in clinical practical application in humans. And theoretical associations and mechanisms of action should not be promoted without huge asterisk to contextualize how often such speculation are wrong.
If you complain about AI slop and don’t see how this is just as bad science slop, please go listen to Sabine Hossenfelder. This is just as bad, and create just as much useless noise as AI content does on the nett.
Once-Weekly Semaglutide in Adults With Alcohol Use Disorder
Results
Forty-eight participants (34 [71%] female; mean [SD] age, 39.9 [10.6] years) were randomized. Low-dose semaglutide reduced the amount of alcohol consumed during a posttreatment laboratory self-administration task, with evidence of medium to large effect sizes for grams of alcohol consumed (β, −0.48; 95% CI, −0.85 to −0.11; P = .01) and peak breath alcohol concentration (β, −0.46; 95% CI, −0.87 to −0.06; P = .03). Semaglutide treatment did not affect average drinks per calendar day or number of drinking days, but significantly reduced drinks per drinking day (β, −0.41; 95% CI, −0.73 to −0.09; P = .04) and weekly alcohol craving (β, −0.39; 95% CI, −0.73 to −0.06; P = .01), also predicting greater reductions in heavy drinking over time relative to placebo (β, 0.84; 95% CI, 0.71 to 0.99; P = .04). A significant treatment-by-time interaction indicated that semaglutide treatment predicted greater relative reductions in cigarettes per day in a subsample of individuals with current cigarette use (β, −0.10; 95% CI, −0.16 to −0.03; P = .005).