Top
Best
New

Posted by rguiscard 12/12/2025

CRISPR fungus: Protein-packed, sustainable, and tastes like meat(www.isaaa.org)
314 points | 236 commentspage 2
docmars 12/13/2025|
I am never going to stop eating beef or poultry, no matter what any scientist or politician thinks about sustainability.

We have been using these as healthy, nutritious food sources for eons. I'm fine with people creating alternatives and making them available, but far too many people want to see the former disappear because they're misled by bad science and hysteria.

fithisux 12/12/2025||
For chickens you do not have to pay license fees for the CRISPR technology.

This is a huge disadvantage. Not every farmer is a biological research institute.

swiftcoder 12/12/2025|
We already have licensing fees for GMO seeds. Can't be all that long before they CRISPR an actual chicken breed, and start charging licensing fees for those as well.
torginus 12/12/2025||
This sounds like they took a product that failed in the market - fungus based meat substitutes, and hinted at some superscience magic thats years from coming out, and that's if it proves safe, economical and a genunie improvement.

This really looks like an attempt to get investors to come back and push the stock price.

andrelaszlo 12/12/2025|
Quorn is based on fungus. I'm not a huge fan of it myself but it's sold across the EU, and it's in almost all stores where I live.
NoGravitas 12/12/2025||
Quorn is fine, but it's neither better nor cheaper than the plant-based fake chicken nuggets, so I'm not super enthusiastic about it.
cregy 12/12/2025||
This! Would love if we spent some of that sweet AI money into engineered new food sources. I've been watching Soylent for a while now. Food that can be made in space is what we need for interplanetary travel. Qudos to this crispr research!
lm28469 12/12/2025||
> Food that can be made in space is what we need for interplanetary travel.

Given how fucked up astronauts who spends just a few month in space come back to earth I think we have dozens if not hundreds of other things to solve before even considering food. Your bones, muscles, eyes, circulatory system, &c. are not made for anything other than good ol earth

rapatel0 12/12/2025||
I have a feeling this will be solved somehow with peptides in the long run
ericmcer 12/12/2025||
We had a pretty huge "fake meat" funding craze in 2021. Beyond meat traded at >$200 for a bit, now it is $1. Not sure why it all burned out and disappeared.
stubish 12/13/2025||
It all burned out because the market for 'fake meat' is tiny, the meat loving ethical or ignorant vegetarians. The vast bulk of the vegetarian market would prefer a lentil burger. In the real market for 'fake meat', it needs to compete economically with factory chicken, which is one of the cheapest protein sources on the planet.
Jeff_Brown 12/14/2025||
What's the protein density? For ordinary mushrooms it's around 2.5% by weight, vs. around 27% for beef.
notepad0x90 12/12/2025||
meet tastes great and all, but I wonder where science is at (if at all) on making original food that tastes good. How about food that doesn't taste like any natural food we've had, but still tastes really good?

Jell-o (gello?) is a good example, nothing tastes like it naturally. Why aren't there tasty food that are original in terms of taste and texture but good for health and the environment? I suppose part of the struggle is that food is entrenched into culture so much. burgers and bbq are inextricable from july 4th and memorial day for example.

awestroke 12/12/2025||
The trouble is that “tastes good” isn’t a blank canvas. It’s built on hardwired signals plus learned associations. Our basic tastes evolved as nutritional indicators: sweet signals energy, umami signals protein, bitter warns of potential toxins. And our brains are rather insistent about finding flavors more pleasant when they match patterns we’ve already learned are safe.

Jell-O actually proves this rather than refuting it. It succeeds because it hits that hardwired sweet preference, not because it invented some novel taste dimension. A truly new taste that doesn’t map onto the existing five basics would likely register as “off” rather than delicious. Your brain wouldn’t know what to do with it, nutritionally speaking.

So you’d have to either work within those existing taste channels while creating novel combinations and textures, or somehow condition people to associate genuinely new sensations with safety and reward. The latter is slow going. We’re quite literally built to be suspicious of unfamiliar foods.

tsimionescu 12/12/2025|||
> A truly new taste that doesn’t map onto the existing five basics would likely register as “off” rather than delicious. Your brain wouldn’t know what to do with it, nutritionally speaking.

We have five taste receptors, so it's it's actually impossible to get something that doesn't map unto those five. Instead, what we call the taste of food, and what GP was referring to, is actually the smell of food, or more commonly, its aroma, which we can detect both from the outside by sniffing it with our noses, and while it is in our mouths via molecules wafting up to our respiratory tract.

Unlike the simplicity of taste, we have a huge array of smell receptors, with most of them having much more indirect associations, if any, with any specific survival need. It's very much possible, and in fact quite common, to synthesize novel smells/aromas which don't resemble any natural food.

9dev 12/12/2025|||
> Unlike the simplicity of taste, we have a huge array of smell receptors, with most of them having much more indirect associations

Slightly unrelated, but what I find very cool is thinking about your taste sense as a hyper-sensitive molecule detector. Individual aromas are just the signal your brain generates for different kinds of molecules, and it's very good at that. That's why at wine tastings, for example, people come up with all these elaborate terms for specific aromas—it's a way to name the molecule composition.

foobiekr 12/12/2025|||
Agreed.

A good example might be one that came up recently (on "Tasting History") is musk, which tastes of and has the bouquet of laundry detergent, or basil (which if you eat it plain and in isolation has a bizarre chemical flavor and bouquet), etc.

majkinetor 12/12/2025||||
> Your brain wouldn’t know what to do with it, nutritionally speaking.

At first. If the food has nutrients that are important to the brain, it will recognize that in the future. There are animal experiment confirming this.

Nevermark 12/12/2025||
The term "acquired taste" quite literally means this.

We don't link a sensation initially, until our mind associates it with feeling good in some way. Then we like it.

notepad0x90 12/12/2025|||
I was not suggesting inventing a new fundamental taste but new foods that are unlike existing foods. "meat" is not a taste for example. I can't give you an example, because that's the whole point, someone needs to experiment and find out. But the fundamental tastes like sweet and umami will remain of course.
edent 12/12/2025|||
There are plenty of "synthetic" flavours - Takis, Twinkies, and bubblegum drinks spring to mind.

There are also a wide variety of textures that are heavily industrialised. If you go to some fine dining restaurants, you'll find smells and colours which you simply cannot replicate at home - let alone make from scratch.

Most synthetic meat and fish is really just a flavour carrier for whatever sauce people like. I've had imitation chicken, shrimp, beef, crab, etc. They all taste great - but that's mostly because the sauces are the same as their meaty counterparts.

qingcharles 12/12/2025||
Right. Chicken is more of a texture than a flavor. When you buy a Spicy Zinger Burger from KFC you're tasting more of the zingy than the cluck-cluck.
dentalnanobot 12/12/2025||
The chicken that KFC uses, sure. There’s a huge difference between that and a chicken that’s been raised well and allowed to get to a sensible age before slaughter.
bcoates 12/12/2025|||
The taste/texture of jello is just collagen (roughly, "meat stew flavor"), fruit juice, and (tons of) sugar. It’s just an extremely heightened version of natural flavors. There is nothing new under the sun.
anon84873628 12/12/2025||
Not to mention that "nothing tastes like it naturally" is false. Plenty of fruits have a jelly like consistency, they're just not common in the modern western world. Consider ripe persimmons, caimito, or abiu. Jelly palm and quince are cooked into literal jelly. Further afield you also have aloe leaf and cooked nopal.
dkbrk 12/12/2025|||
Your question is rather ambiguous. Do you mean using chemistry to develop new techniques or combine unusual ingredients to create food that has novel flavors or textures? That would fall under Molecular Gastronomy, which has been highly influential within fine dining in the last few decades.

Do you mean processing ingredients with the goal to take cheap ingredients and make a product as hyper-palatable as possible? That would generally be called "ultra-processed food"; you're not going to find a Doritos chip in nature.

Do you mean developing completely completely new flavors via chemical synthesis? I don't think there's much possibility there. Our senses have evolved to detect compounds found in nature, so it's unlikely a synthetic compound can produce a flavor completely unlike anything found in nature.

Also, I think you're overestimating jelly. Gelatine is just a breakdown product of collagen. Boil animal connective tissue, purify the gelatine, add sugar and flavoring and set it into a gel. It's really only a few of techniques removed from nature. If you want to say it's not found in nature, then fair enough, but neither is a medium-rare steak.

notepad0x90 12/12/2025||
I mean using chemistry to create food using atypical ingredients that aren't normally classified as food or entirely synthetic. Take more simpler or more abundant compounds to create original food instead of using plants and wildlife. Flavors don't need to be new, but as others mentioned there are plenty of recently invented flavors. Doritos is ultra-processed corn, what i'm saying is Doritos but there is no corn involved. The original article is about meat-like food, I was saying "why meat-like" , if it is food that has similar taste like meat, that's fine, but it doesn't need to be like meat, it just needs to taste good and have palatable texture. Maybe we can have something tastes better than meat!
sp4nner 12/12/2025|||
You may be interested in the biotech startup Oobli <https://oobli.com/>. They're attempting to commercialize a protein-based sweetener, where the protein itself is interacting with your taste receptors and registering as 'sweet'.

The technology is based on some naturally occurring proteins from fruit native to West Africa, but I'd say the idea of sweet things that are good for you is pretty novel!

Certhas 12/12/2025|||
I find this highly annoying. Here we've had very tasty wheat based slices that can serve the same purpose as sliced salami/meats on bread, and didn't try to muck anything in particular. But they disappeared from the shelves while the stuff branded as Vegan Salami seemingly does well.

I guess for casual buyers having a familiar reference point is just crucial.

refactor_master 12/12/2025|||
The crusade against gluten probably did it. Tofu lives as un-refrigerated grey blobs and tempeh never even made it to the shelf, probably because of hormone-disrupting soybeans. But hyper-engineered single cell meat? Now that’ll sell.
NoGravitas 12/12/2025||
Tempeh is pretty common at health food stores. More common than seitan, less common than tofu.
gs17 12/12/2025||||
This is really frustrating to me, it's hard to find seitan outside of Chinese shaokao (BBQ skewers) restaurants. There's a local brand of wheat-meat that even runs a deli that's pretty good, but people are so afraid of gluten.
throwaway808081 12/12/2025|||
That's because 166.2% of the population are allergic to wheat.
aydyn 12/12/2025|||
Jello doesnt really have much taste by itself. what youre tasting is mostly sugar.
globular-toast 12/12/2025||
Plus small amounts of perfumes similar to fruits or other bits of plants, usually.
Vanit 12/12/2025|||
Like you said I think it's culture, particularly ones that are food oriented. It's gonna be hard to get buy-in if people think it's too weird.
h-c-c 12/12/2025|||
I'd argue that Jell-o tastes good because sugar tastes good and that it's just the novel texture coupled with sweetness that is the attraction. I doubt many people know what unsweetened gelatin tastes like or if that even tastes good.
isodev 12/12/2025||
> doesn't taste like any natural food

Remember the target audience - people would rather drink and die from raw milk than get a shot for a completely preventable sickness.

cwillu 12/12/2025||
I have all my shots and drink pasteurized milk, and I prefer familiar chicken-like substances over experimental cuisine.
pstuart 12/12/2025||
Another angle for sustainable protein: https://www.airprotein.com/

Details are a bit vague but it seems like it's viable.

inkcapmushroom 12/12/2025|
I wish they would just say what's producing the protein. "Our cultures" and talk of fermentation makes me think it's just yeast maybe?
pstuart 12/12/2025||
Yeah, considering the age of the project that inspired it, yeast would be a good bet. Hopefully they do well and we learn more about it; we need all the options we can get to feed the planet in a sustainable manner.
SilentM68 12/12/2025||
When I hear the word fungus, I think of "The Last of US" ;(
Bad_Initialism 12/12/2025||
The association is undiminshed by their web server being down. Uh oh.
brnt 12/12/2025||
That would make for a great spinoff: farm the infected for food!
SilentM68 12/12/2025||
It seems that when the apocalypse finally arrives, I will skip the Michelin stars and go straight to nightmare cuisine.

Soylent Green is People, too!

Sighhh, Sol Roth ;)

api 12/12/2025||
This would be outstanding for organic recycling in space.
theultdev 12/12/2025|
We've gone from GMOs are bad to lab meat being okay.
Arch485 12/12/2025|
Well, no, I know a lot of people who think lab meat is seriously NOT ok (these are the same people who think GMO corn will somehow kill you).
theultdev 12/12/2025||
Most comments here are pretty positive, other than noting it's not like meat. But nothing really about health aspects.

I'm fine with GMOs, a lot of produce would be pretty inedible without it.

It's a lot more natural then what we're doing here.

More comments...