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Posted by rbanffy 12/22/2025

Ultrasound Cancer Treatment: Sound Waves Fight Tumors(spectrum.ieee.org)
343 points | 119 commentspage 2
jmward01 12/22/2025|
The advancements in imaging, cheap intelligence and non-invasive (mostly) tools like this are amazing. I can easily see a future where we can scan, and analyze, every cell in a body and then selectively manipulate them to achieve the desired effect. I doubt we are actually that far away actually.
mcbain 12/22/2025||
Previously: https://news.ycombinator.com/item?id=45514378
Nevermark 12/23/2025||
Being non-invasive and incredibly precise, this could be a fantastic therapy for brain cancer treatment.

Assuming the costs of the precise powerful machines needed are not too high (this isn't anything like MRI), it could be a therapy for almost any kind of cancer tumor, and even small potential/pre-cancer tumors that are safe to remove without bothering to do a diagnosis.

PaulHoule 12/22/2025||
In general there is a lot of work on ultrasound stimulation now, some of it is scary in other ways:

https://www.nature.com/articles/s41467-025-65080-9

which could imaginably lead to wireheading or something like Niven's "tasp".

gsf_emergency_6 12/23/2025|
There's also

https://news.ycombinator.com/item?id=46008332

Are these guys losers,clueless, or born psychopaths?

I hope for another category :)

PaulHoule 12/23/2025||
Well when I was younger I was into chemical yoga, and you know I lived this one: https://www.youtube.com/watch?v=N6uEMOeDZsA
aebtebeten 12/24/2025|||
https://www.youtube.com/watch?v=LeHlvXvG6vA
PaulHoule 12/27/2025||
… those ones that mother gives you that don’t do anything at all!
gsf_emergency_6 12/27/2025|||
In response to

https://news.ycombinator.com/item?id=23475069

It seems that "third-person first" encapsulates the ALARM theory perfectly..

(Shannon's game "antibootstraps": if the machine loses twice in a row, it acts to prevent the human from learning its own strat. The "insurance[1]-dual" ? :)

In https://mastodon.social/@UP8/113189883152005058

The bottom box is labelled "emptiness, void, etc". its archaic nature would suggest it's that primordial "third person"?

[1] as usual, a shorthand for Morelly's

https://en.wikipedia.org/wiki/From_each_according_to_his_abi...

Which also points to

https://en.wikipedia.org/wiki/Solidary_obligations

>Contractual solidary obligations are frequently created by insurance policies

(take on solidarity v love-- later..)

>The origin of solidarity can be traced to a Roman idea known as correality where a single thing was owed by more than one person [but only one person need ever be accountable for it]

aebtebeten 12/27/2025||
In games where any given strategy is potentially exploitable, I guess the meta is (a) rapidly decide if you're playing against a fish, or if you are the fish; then (b) if against a fish, exploit their strat, or (c) if you are the fish, run a mixed strat, to at least avoid yours being exploitable.

Bottom box as primordial "third person" would go along with egolessness in various traditions (including 李小龙's "be water, my friend")? EDIT: https://ctext.org/dao-de-jing#n11598 ?

Note that solidarity from roman law was directly taken up by civil codes, but HN's home country is a common law jurisdiction: https://en.wikipedia.org/wiki/List_of_national_legal_systems...

("joint and several liability" seems to cover passive, but not active, solidarity?)

gsf_emergency_6 12/29/2025|||
https://www.thenandnow.co/2023/06/24/adorno-and-horkheimer-d...

Not like water? Or just like water?

https://archive.ph/2025.12.29-103422/https://baike.baidu.com...

Could be explained by a dichotomy* between "intuition" and "deliberation" 刻意(尚行)? A sorta Buxton mechanism.. (intentionally avoiding "saddles" "minima" or whatnot :)

The former "turns enlightenment into myth" (cf again Horkheimer+Adorno)

*Gemini tells me that the best approx to "creative disruption" is [eu]kainotomia

aebtebeten 12/29/2025||
老子, despite being generally contra, had the option of deliberation; intuition* ("having the proper action in cache") was the only timescale available to Lee.

* is it intuition, or is it following a geodesic on (your foliation of) the Lagrangian?

gsf_emergency_6 12/30/2025||
Lee? Ah! (Was distracted by santu gonger <-> )

https://baike.baidu.com/item/%E4%B8%89%E5%85%94%E5%9B%BE/107...

I'm still trying to internalize+merge the other sense of Lagrangian (as in "L submanifold")

gsf_emergency_6 12/27/2025|||
(If we replace fish by "unicellular organism", it might be easier to get to "what kind of (meta)game gets them to multicellularity"?)

Note that narcissism is what PH/Kohut is trying to breakup here. I struggle to put egolessness at its foundation, because that smells too much like nihilism. seem s increasingly less healthy to scale nihilistic therapy to a handful, 37 (~Dunbar), 1000s (POUM outer party?)

Why not an alternative life-force that could legitimise the "ri" in shu-ha-ri, "acting-out", "disruption" (so take it both personal and ... solidarital (-activism)?)

[Creative] disruption is after all the unspoken (meta?)ideology on HN*

Fully hypothetically, we shall then consider the behaviour of "(self-)therapists" in that scenario- "weaponized curiosity" bootstrapping into a full alarm ---as "we" model the minds running a "Bildungs"-institution (PH), the spiessig (aeb), HN mods (yours truly) :)

(I'd like to take it here to "self jokes or -tickling", but "too many knobs spoil the chat".. EDIT to circle back to civil vs common systems wrt fueling creative disruption soon enough)

*Seems like a step up from "Schumpeterian" "creative destruction"/will-to-power tbh

aebtebeten 12/28/2025|||
(fish in the poker sense, if that wasn't clear)

Right, I just think Kohut's third box (we are talking about the bottom one, right?) may be just as profitably looked at through the "egolessness" prism as through the "integrated" prism.

Looking through the shu-ha-ri prism, I could see the top two boxes as being symptomatic of the "ha" stage: breaking the rules with grandiose intentions usually leads to worthless results? In this model, there are two paths out: a retreat from frustration, back into "shu", or a tunnelling through frustration, onwards into "ri"?

(to what degree might tunnelling relate to LLM "double descent"?)

Speaking of "weaponized curiosity", I once ran across a recommendation for determining which puppies to bother attempting to train as hunting dogs: https://news.ycombinator.com/item?id=41488445

gsf_emergency_6 1/3/2026|||
ELI5 which features of double descent evoked tunnelling to you?
aebtebeten 1/6/2026||
If we look at "twice made dips", we say two times as there is first a dip, then a peak (rise and dip), and then the next dip. This is like when one hops the band gap: there is first a free wave, then one that looks like it dies out, but if it is still a bit big by the end of the gap, then it goes on to the next free wave.
gsf_emergency_6 1/7/2026||
Bloch oscillations? Didn't see that coming tbh. ELIgs then
aebtebeten 1/7/2026||
No, not so fancy (do they arise from interference from the internal reflections?).

In standard tunnelling, one starts with a normal oscillation, goes to evanescence in the "tunnelling" regime, and then continues with oscillation again once on the low side of the potential; in double descent the test error goes way up (like the potential earlier) in the "tunnelling" regime, and then on the far side comes back down and then continues descending.

Have I explicated my model?

gsf_emergency_6 1/8/2026||
Why say "bandgap" when you mean "potential wall" :)

So test-error is sampling a (thermodynamic) potential?

aebtebeten 1/11/2026||
I don't think really so; just riffing off a similar "surfer dives under a wave" pattern — but if you could make it work I'm all ears!

None of "confinement", "energy", or "level" work in my take on "ELI5"; that is why :)

(when I have more time should I try an eight part 文 in words like this?)

aebtebeten 12/28/2025|||
now that I've skimmed a bit of Kohut (and struggled with the Freudian terminology), it's probably worth pointing out that I was using "egolessness" in the ordinary sense above, not in Freud's tripartite technical sense.
gsf_emergency_6 12/29/2025||
Let's call the ordinary sense "anatman" (soulless?) and in the context of PH's reintegrated chart "cosmic narcissism"..

Will merge these streams into a more recent stub--

gsf_emergency_6 12/27/2025|||
Not mother (or one of the universal mascots of fecundity[1]) only something to feed the festive fire

https://news.ycombinator.com/item?id=45955649

(By way of an "explanation" of the "3 boxes")

[1] https://en.wikipedia.org/wiki/Three_hares

>There are two possible and perhaps concurrent reasons why the three hares may have found popularity as a symbol within the church. Firstly, it was believed that the hare was hermaphrodite and could reproduce without loss of virginity.[26] This led to an association with the Virgin Mary, with hares sometimes occurring in illuminated manuscripts and Northern European paintings of the Virgin and Christ Child.

aebtebeten 12/27/2025||
The wine grape is hermaphrodite; could that have something to do with transubstantiation?
gsf_emergency_6 12/27/2025||
Then "J" must be..
aebtebeten 12/28/2025||
..haploid? (why else the middle initial of "H"?)
gsf_emergency_6 12/23/2025|||
This to the other one that made the end credits of BtTF is as Sixto to Dylan :)
darkerside 12/22/2025||
Dumb question, but isn't there a risk of spreading cancer causing proteins throughout the body with this approach?
ramraj07 12/22/2025||
Cancer isn't caused by proteins in the way you might think. Its definitely not infectious at the protein level. You could ask if this disruption spreads out cancer cells themselves and that would be fair to ask. But then the cancer cells were already in your body and were likely trying to migrate to other sites anyway.
amelius 12/22/2025||
Ok, but this might stimulate migration further.
sowbug 12/22/2025||
The success of surgery to remove solid tumors usually hinges on whether there are "clean margins," meaning they were able to remove all the bad tissue and a little good surrounding tissue just to be sure. It's likely that the same principle applies using this new procedure: if you blast the whole thing and trust the body to clean up the mess, hopefully there won't be anything left to worry about.
darkerside 12/23/2025||
> trust the body to clean up the mess

This is what I'd like to understand better, rather than operate on trust. A couple of other commenters have shared good context.

ramoz 12/22/2025|||
> Histotripsy generally seems to stimulate an immune response, helping the body attack cancer cells that weren’t targeted directly by ultrasound. The mechanical destruction of tumors likely leaves behind recognizable traces of cancer proteins that help the immune system learn to identify and destroy similar cells elsewhere in the body, explains Wood. Researchers are now exploring ways to pair histotripsy with immunotherapy to amplify that effect.
jjtheblunt 12/22/2025||
the article talks about this, the (too vaguely explained) tldr is that pulverization allows neoantigens to be exposed to the immune system rather than hidden within a tumor. i saw elsewhere (weeks ago) an article that this worked excellently, but this article seems to not reference it.

this is one such article:

https://viterbischool.usc.edu/news/2025/11/tricking-tumors-i...

aitchnyu 12/23/2025||
Will this be applicable to belly/visceral fat? It could be wildly popular.
throwup238 12/23/2025|
Yes. There are several methods like high-intensity focused ultrasound (UltraShape and Liposonix) and the ultrasonic cavitation found in medspas.

The former is somewhat effective but based on early research shares the same problems as other active fat loss treatments: lysing the fat cells causes all the relevant hormones to get released into the bloodstream, causing reabsorption by other fat cells. It’s a very gradual process and quite expensive.

buu700 12/23/2025||
Thanks for posting this. Sounds super promising, and the explanation of histotripsy's mechanism of action is compelling.

Given the 2023 approval (for liver tumors) and oversubscribed $250m funding round announced in October, it seems like there's a ton of momentum behind this. I also see that the treatment is available at my local hospital system (Inova), which is an encouraging sign of its general availability.

Anyone who's commenting to ask whether it's an option for you or a loved one, check your state's right-to-try laws. Virginia and various other states do apparently have right-to-try laws that cover medical devices: https://triagecancer.org/state-laws/righttotry.

Fuck cancer.

KnuthIsGod 12/23/2025||
A random popular article on ieee.org is not a Phase 3 RCT published in the NEJM.

Click bait is click bait but reliably reels in the gullible.

maxdo 12/23/2025|
from purely physics , how is cancer cell different from regular cell to react with ultra/infra? is it so different?
rincebrain 12/23/2025|
It's not.

The key thing is, one of the things most tumors need to do to get past a certain point is avoid getting caught being tumors.

If you can very selectively cause precise tissue death, from any method, then your body will suddenly start looking askance at any tissue that looks like the secretly-full-of-tumor-markers corpse it just found.

And ultrasonic cavitation means you can, in theory, cause very precise tissue death with even less surrounding effect than radiation.

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