Researchers discover molecular difference in autistic brains

Posted by amichail 12/28/2025

Researchers discover molecular difference in autistic brains(medicine.yale.edu)

224 points | 138 commentspage 2

ijustwork 12/29/2025||

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mapontosevenths 12/29/2025||

This was studied because it sounds reasonable on paper and several small studies showed a small link.

However, they did a very large cohort study with hundreds of thousands of subjects. The link completely disappears when genetics are accounted for via sibling pairs.[0]

It took almost two whole minutes of Googling for me to disprove this nonsense. Which shows that RFK did less than 2 minutes worth of research before panicking the world.

[0] https://jamanetwork.com/journals/jama/fullarticle/2817406

SubiculumCode 12/29/2025|||

I will say that this study presented a major challenge to the tylenol hypothesis. To my mind, there is still a remote possibility that the tylenol hypotehsis might just be relevant to a smaller subset of autistic individuals...but I am coming from the general outlook of believing autism needs to be subtyped when looking at etiology.

mapontosevenths 12/29/2025||

Personally, I very much agree. I feel that while the idea of a spectrum wasn't a mistake, it was only a start.

api 12/29/2025|||

But did you check the vibes?

mapontosevenths 12/29/2025||

I did, but I'm on the spectrum so I failed the vibe check. ;)

tomerico 12/29/2025|||

Didn’t whole internet get angry for Trump’s administration publishing a warning that Tylenol during pregnancy may cause autosim?

ijustwork 12/29/2025|||

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mapontosevenths 12/29/2025|||

Anything claimed without evidence can be dismissed without evidence.

perching_aix 12/29/2025|||

> propaganda mouthpieces

Bit rich coming from a sockpuppet account created 57 minutes ago...

- exclusively commenting on this thread

- uncritically addressing it from a very specific angle

- mentioning specific things that sound related while not actually connecting them to the overall story with the same rigor

...isn't it?

MangoToupe 12/29/2025|||

Can you explain the logical leap you're making here? Unless this is RFK Jr we're talking to, you're comparing two wildly different contexts.

ijustwork 12/29/2025||

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MangoToupe 12/29/2025||

The logical leap

ijustwork 12/29/2025||

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diydsp 12/29/2025||

The vaccine autism hoax is traced back to one specific discredired researcher:

https://time.com/5175704/andrew-wakefield-vaccine-autism/

ijustwork 12/29/2025||

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muglug 12/29/2025|||

Please don’t use a bunch of traumatised parents as a medical reference either. The science is extremely clear that Wakefield was a bad scientist — see https://en.wikipedia.org/wiki/Fraudulent_Lancet_MMR_vaccine-...

slater 12/29/2025|||

please don't use "many parents" as a medical reference

tryscience 12/29/2025||

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mapontosevenths 12/29/2025|

https://jamanetwork.com/journals/jama/fullarticle/2817406

truseek 12/29/2025||

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wizzwizz4 12/29/2025|

Re-posting a flagged and dead comment under a new account is not acceptable behaviour. https://news.ycombinator.com/item?id=46416138

try2stopme 12/29/2025||

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slater 12/29/2025|

stop already with the sockpuppet accounts

Hnrobert42 12/28/2025||

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gchamonlive 12/29/2025||

It would also be interesting if there's no link to be found.

Hnrobert42 1/3/2026||

Of course. That's what I expect.

lez 12/29/2025||

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Uptrenda 12/29/2025||

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gerdesj 12/29/2025||

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ziofill 12/29/2025|

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