Tamarind hosts AI drug discovery models for biotech/pharma researchers. We’re building the infrastructure to power R&D in pharma companies and enable them to harness the latest advancements in computational biology, such as molecular ML models like AlphaFold.

We're hiring engineers who are excited to scale GPU inference, design intuitive applications for scientists, and build secure enterprise-grade software. We’re a series A company started 2 years ago, and have 10x’d revenue within the past year. We’re used by 7 of the top 20 pharma, dozens of biotechs, and tens of thousands of scientists. We’re hiring for a variety of engineering roles, including generalist software engineers and infrastructure engineers. We value ownership, moving quickly, and a focus on customer needs.

Stack: AWS, Python, React, Javascript, Kubernetes

Apply here: https://www.ycombinator.com/companies/tamarind-bio/jobs or email me at sherry@tamarind.bio.

We are seeking an experienced DevOps Engineer to join our team full time. Big Cartel is dedicated to empowering the independent seller with affordable e-commerce tools. We are a 100% independent, bootstrapped, tight-knit team dedicated to our mission of aiding individuals and small brands in setting up shop and making a living doing what they love. Candidates must be US residents at this time. For more details please check out our job posting here: https://bigcartel.recruitee.com/o/devops-engineer

PowerSync is a sync engine that keeps your backend database in sync with on-device SQLite. We support Postgres, MySQL, MongoDB and SQL Server as source databases and have a plethora of client SDKS, many of which are integrated with popular libraries and frameworks on the client-side like TanStack DB, Drizzle, GRDB, Room, etc

If you're a database enthusiast and have a solid track record of building, deploying and maintaining backend systems on modern cloud stacks at scale, please check us out.

Detail: https://www.powersync.com/careers/senior-backend-engineer-an...

Our team is small and polyglot, but experience with TypeScript is a must.

Experience with OSS projects is also a must - either you've made significant contributions to popular devtool projects or, better yet, you have your own.

Culture: We're agile and devops purists (before those terms got coopted)

EQTY Lab is focused on emerging governance and security paradigms for AI infrastructure. Our primary focus is verifiable computing using cryptographic capabilities to identify and govern agent behavior.

We're also focused on helping the industry advance with frontier tooling. From requesting the hooks feature in Claude Code, to building our own open-source integrated capabilities such as https://github.com/eqtylab/cupcake - we will continue to explore and share the things we develop for coding agents or any frontier tooling enterprise is quickly adopting.

We're seeking software engineers across the full stack. To include,

    - engineers interested in governance tooling
    - sdk writing in TypeScript or Rust
    - or engineers with cryptographic security domain experience
    - or deeper hardware level focus (platforming on Kubernetes - confidential computing, custom firmware as it relates to GPUs).

Please email me directly: ramos@eqtylab.io

Clever Benefits is hiring a Senior Full Stack Software Engineer to help build and scale our platform. You’ll ship end-to-end features across a React web app, React Native mobile app, Node.js/TypeScript backend, and AWS infrastructure. Small team, high ownership, production focus.

Stack: TypeScript, React, React Native, Node.js, Prisma, PostgreSQL, tRPC, AWS (Lambda, ECS/Fargate, S3, RDS), CI/CD.

Requirements: 8+ years experience; strong TypeScript; production React + React Native + Node; solid AWS background; Prisma/Postgres/tRPC; comfortable owning features from design → deployment. Must live within 30 miles of North Scottsdale and be able to be onsite 2 days/week.

Nice to have: TestFlight/Play Store workflows; monorepos (pnpm/bun workspaces); IaC (CDK/Terraform). Interest in using AI to accelerate development (codegen/automation) — with an emphasis on maintainable, high-quality engineering.

How to apply: Email your resume + a short note (and links/GitHub if you have them) to sal@cleverrx.com with subject “HN — Senior Full Stack Engineer”.

Commercial Real Estate (CRE) is the world’s largest asset class. The annual transaction volume is 10% of US GDP, yet the industry remains slow and archaic because data is locked in PDFs and Excel files. We are transforming CRE into an AI-native asset class by helping investors understand their own assets better.

*We are hiring in NYC:*

Senior/Staff AI/IE engineer (NYC)

- Architect RAG/prompt systems to parse heterogeneous structured data. - Develop frameworks connecting LLMs to quantifiable investment decisions. - Collaborate with finance experts to translate domain knowledge into code.

Senior/Staff Full-stack engineer (NYC)

- Own the infrastructure and UI that power high-value investment decisions. - Design scalable data pipelines and cloud architecture. - Tackle complex business logic with domain-driven design.

*Who are you:*

- You build things for fun, obsess over craft, and have a lot of product ideas. - You have proven experience shipping production software to solve *ambiguous business problems*. - You have experience with end-to-end NLP/IE and complex data extraction.

The world doesn't need another ERP. CoPlane is building the Agentic Orchestration platform that enables enterprises to orchestrate intelligent processes across their existing systems. Founded by ex-Stripe/Segment product and tech leads, we're changing how businesses operate their backoffice - helping them scale intelligence not headcount.

We're looking for an exceptional design engineer to grow our small team of engineers that include ex-founders, open source contributors (authors of neovim and neverthrow), and architects of petabyte-scale data platforms. You'll work with billion-dollar enterprises solving their hardest, most mission-critical automation problems.

If you're excited about working at the nexus of data, automation and AI, and want to make a significant impact in an early, well-capitalized startup with large enterprise design partners, we'd love to hear from you.

Roles: Product/Design Engineer.

For more info and to apply: https://coplane.com/careers

NobodyWho is making developer tools for running small language models in local-first applications. Our core principle is to ship the model weights along with the application, and then do efficient inference locally and offline, on any device. We run fast on Linux, MacOS, Windows, Android and iOS.

The main product is an inference library that wraps llama.cpp, written in Rust. We provide bindings for Python, Godot (the game engine), and will be releasing a Flutter plugin soon. It's all licensed under EUPL 1.2. Repo here: https://github.com/nobodywho-ooo/nobodywho/

We're hiring people who are comfortable building highly cross-platform FFI applications in Rust (with C++ dependencies), and people who are deeply familiar with language models and the open standards around them, as well as fine-tuning and evaluating models. We're also looking for a technical DevRel profile.

If any of that sounds relevant to you, feel free to email me: a>at<nobodywho.ooo

Gauge helps companies show up in more AI answers. Search traffic is shifting away from Google into AI chat, and companies are figuring out how to adapt right now. Our system delivers real-time analytics derived from millions of LLM answers, while providing an intuitive, powerful UX. We also generate optimized articles to improve our customers’ visibility, and offer an agentic chat interface over their data (think ‘Why was there a spike on 12/10?’ or ‘Which of my pages should I refresh?’).

I'm Evan, the CTO, and we're looking for engineers with strong programming fundamentals, creative problem solving skills, and a high-agency working style. You might be a good fit if you are an ex-founder, ex-founding engineer, or have worked at a Seed/Series A startup.

We primarily use Django, React, Postgres, Celery, and Clickhouse.

Contact me with your resume (and mention HN) if you're interested: evan[at]withgauge.com

More details/JD also here: https://www.ycombinator.com/companies/gauge/jobs/qemTjv7-fou...