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Posted by aldarion 1/7/2026

Sugar industry influenced researchers and blamed fat for CVD (2016)(www.ucsf.edu)
797 points | 501 commentspage 3
__0x01 1/7/2026|
My understanding was that atherosclerotic plaques are comprised of cholesterol or fatty deposits [1] and that these can lead to CVD.

The fat mechanism I understand, but what is the mechanism for sugar in CVD?

[1] https://www.heart.org/en/health-topics/cholesterol/about-cho...

ericmcer 1/7/2026||
CVD requires a bunch of events to happen in sequence, I always felt like it was a combination of risk factors + luck that make a heart attack or aneurysm happen.

1. High blood pressure damages walls of arteries and veins

2. LDL Cholesterol gets into the damaged walls

3. LDL gets oxidized

4. White blood cells engulf oxidized LDL and form plaques

5. Hardened plaques chill, they are bad but not deadly, if a plaque breaks off you are probably dead.

Sugar is gonna contributes to 1 - 3, especially 3 it seems way more guilty of than fat. The one big thing that opened my eyes was that most of the LDL you get is going to be produced by your own liver. Regulating how the liver produces it is going to have a bigger impact than directly eating less/more of it.

It is kind of a luck thing though, you could eat like shit and never have all the events occur just due to dumb luck, or you could be a fit 45 year old and for whatever reason you get a plaque that breaks off and you aneurysm and die.

heisenbit 1/7/2026||
And the liver produces triglycerides from fructose which is half of sugar.
tsimionescu 1/7/2026|||
Consuming cholesterol doesn't normally change the level of cholesterol in your bloodstream - it simply leads to your body producing less cholesterol. Unless you're consuming gigantic amounts, or have some problems with your cholesterol regulation, dietary cholesterol is completely safe. It's only if your blood work shows elevated cholesterol levels that you need to start paying attention to cholesterol intake. This is in fact very similar to what happens to blood sugar levels, in fact.
giacomoforte 1/7/2026|||
Pretty much every health authority will tell you that high blood sugar damages blood vessels, thereby enabling the formation of said plagues.
loeg 1/7/2026|||
Healthy adults consuming some dietary sugar doesn't cause persistent high blood sugar, though. That's diabetes.
Alex2037 1/7/2026||
it's not just sugar. https://en.wikipedia.org/wiki/Glycemic_index#Grouping

all simple carbs are the devil, but we can't possibly feed billions of people actually healthy food - organic vegetables, nuts, and animal products, so come drink your corn syrup.

loeg 1/7/2026||
The sugar industry (topic of this article) can only be blamed for sugar, though -- not all high-GI foods.

And you can replace "sugar" in what I said earlier with "high-GI foods" and it doesn't change a thing. Persistent high blood sugar is diabetes; it isn't dietary.

Alex2037 1/7/2026||
>Persistent high blood sugar is diabetes; it isn't dietary.

how is it not dietary if consuming most carbs spikes your blood sugar for hours, which, with three meals + snacks + starbucks slurry, means elevated blood sugar 20+ hours a day?

rzmmm 1/7/2026||
It doesn't happen in non-diabetic people. It's different in type 2 diabetics who will see large swings in blood fat and glucose after meals.
__0x01 1/7/2026|||
Please can you provide a source for the above?
aldarion 1/7/2026|||
Sugar causes inflammation, and inflammation damages arteries. It is this damage that then leads to accumulation of fatty deposits, as damaged arteries basically lose the protective layer (think of equivalent to a non-stick coating). But that doesn't mean dietary fat is what actually caused the plaque.
hinkley 1/7/2026||
Poor dental health also contributes and nothing pushes poor dental healthy like a high sugar diet.
WheatMillington 1/7/2026||
It would be cool if researchers weren't so easily bought. I thought the sciences attracted people of strong moral character but it would appear not.
gowld 1/8/2026||
Anoy other greybeards remember this one?

https://www.nytimes.com/2002/07/07/magazine/what-if-it-s-all...

What if It's All Been a Big Fat Lie?

By Gary Taubes July 7, 2002

p0w3n3d 1/8/2026||
Sugar got into all the meal we have, and because it is so addictive, we went for it. Fatty meals are more healthy, especially for me, but will get you sick in no time, unless you eat healthy fats (olive oil, olives especially). The trans fats are carcinogenic
mediumsmart 1/8/2026||
So most of these fat people today are a result of the low fat doctrine forged in the 70’s?
diggyhole 1/8/2026||
Many such cases.
aldarion 1/8/2026||
Yes.
indubioprorubik 1/7/2026||
Should make flour from it: https://www.sciencedirect.com/science/article/pii/S266716032...
slicktux 1/7/2026||
I feel like the same thing is happening now… processed foods have less sodium and I feel are more sugary. I don’t live a sedentary lifestyle…I need salt for hydration and muscle contraction. I find the new nutrition guidelines for sodium lacking.
kudeyar 1/11/2026||
My workplace has a canteen where a hundred people eat together. it's obvious who is destined for medical misery.
xthe 1/7/2026||
The 2016 JAMA paper illustrates how funding sources can shape research focus, reinforcing the value of transparency and multiple lines of evidence in nutrition research.
FlyingBears 1/7/2026|
I avoid sugar pretty thoroughly, but my cholesterol is high because I can't walk past a breakfast sandwich. This an n=1 observation.
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