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Posted by pseudolus 7 days ago

Nuclear receptor 4A1 linked to health effects of coffee: study(sciencex.com)
https://en.wikipedia.org/wiki/Nuclear_receptor_4A1
146 points | 115 commentspage 2
lofaszvanitt 5 days ago|
Coffee is a substance that makes you more susceptible to certain stimuli
RickJWagner 6 days ago||
I was never a coffee drinker, but I became interested because what was said in Arnold Schwarzenegger‘s newsletter. ( There is a ton of medical research covered in there. )

I didn’t dig in too deeply, but started drinking a morning cup of sugar free double mocha cappuccino, to help my workouts.

If I’m fooling myself, don’t tell me. I like the cappuccino.

rhyperior 6 days ago|
Episode #103, @FoundMyFitness on Spotify podcasts. All about coffee’s benefits, including for exercise.
soupspaces 6 days ago||
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wotsdat 6 days ago||
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zingababba 6 days ago|
Nice, maybe it balances out nicotine. People who don't pair caffeine with nicotine simply have no clue what they are missing ;)
neya 6 days ago||
> People who don't pair caffeine with nicotine simply have no clue what they are missing ;)

We do, and that's called cancer;)

jonnybgood 6 days ago|||
Is there research that links nicotine to cancer? I’m unable to find anything that would suggest nicotine as cancer causing.
cf100clunk 6 days ago||
Are you researching whether you'll get cancer if you are extracting 100% pure nicotine and ingesting it? Who does that?
coffeebeqn 6 days ago|||
Most nicotine users today? Everyone’s using the pure nicotine pouches like zyn and such. I didn’t really find it enjoyable at all
raducu 6 days ago||
> Most nicotine users today?

I did use pure nicotine and it was very bad for my health, probably due to high dosage, but still.

I've used heavy stimulants, benzos, opioids, dissociatives without an issue, but nicotine is in a class of its own in terms of how insidiously addictive it is.

But just from a health point of view: extreme arm and hand joint issues, forearm vascular issues that made my hands numb at night, palpitations/arrithmia like I was about to die when I used nicotine before sleep and I was drifting to sleep -- it really felt like I was about to die, like my heart was mangled up.

steve_adams_86 6 days ago|||
A lot of people consume nicotine. It has been isolated and used in products for a long time. There's no clear link to cancer, but it could impact cardiovascular health (like all stimulants seem to).

Some research indicates that nicotine can influence how existing cancer behaves and spreads, so that's worth considering.

cf100clunk 6 days ago||
Right, point taken, but I wasn't following how nicotine properties were connected to coffee's health benefits.
christophilus 6 days ago|||
He was suggesting— jokingly— that maybe coffee cancels out the deleterious effects of smoking, because indeed coffee + a cigar or pipe is truly an excellent experience.
steve_adams_86 6 days ago||
Mentat-mode engaged
Tagbert 6 days ago|||
zingababba started this thread talking about mixing caffeine and nicotine.
gavmor 6 days ago|||
It's the endothelial dysfunction, oxidative stress, increased arterial stiffness, and accelerated atherosclerosis that turn me off.
maximinus_thrax 6 days ago|||
I quit smoking a long time ago but if there's one thing I'm missing / craving is a hot cup of coffee with two cigarettes on an empty stomach during cold winter mornings... Fuuuuck.
sfpotter 6 days ago|||
"Serious delirium!"
soupspaces 6 days ago||
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