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Posted by supermatou 4 hours ago

Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years(jamanetwork.com)
156 points | 74 commentspage 2
p-o 2 hours ago|
I don't know, the study seems pretty mild in findings and the research doesn't mention anything about the socioeconomic environment in which each of the children grew in.

Maybe it's the high dose vitamin, maybe it's because one cohort was skewed one way on the socioeconomic spectrum, maybe it's something else entirely. More evidence would be needed imo to confirm Vitamin D3 has a direct contributor to cognitive performance as the research portrayed.

bootsmann 2 hours ago|
> the research doesn't mention anything about the socioeconomic environment in which each of the children grew in.

The main trick behind randomized control trials is that you can disregard factors like this because these effects would be randomly distributed as well.

p-o 2 hours ago||
Not always, and in this case, the study is very light on details on how the selection process was done. The burden of the RCT is on the research team and the quality of the randomization varies between studies.

If a study is going to draw debatable conclusion after 10 years on high dose Vitamin D during pregnancy, I'd expect at least some comment in the study on the general socio economic landscape and grouping.

Regardless, this study looks like a sham to me.

dzonga 2 hours ago||
high dosage vitamin D in kept me sane (i.e energetic & in the right mood) in the UK where it's usually gloom & drowsy.
gib444 1 hour ago|
What dosage?

> in the UK where it's usually gloom & drowsy

Luckily this is only September through to July :) ... :(

simianwords 1 hour ago||
Serious: when I take Vitamin D3 I get all washed up and feel hungover for multiple days. It looks like few people have this reaction.

Anyone has any leads on this? Why is this happening? Doctors deny it and my levels are low.

OutOfHere 2 hours ago||
Meanwhile, the endocrine society is still murdering millions by asking people to not supplement vitamin D3 and to explicitly not test for it either. The times must be tough for endocrinologists with people supplementing high-dose vitamin D3 and testing routinely to ensure an optimal level, tough enough to want to keep people very sick.
soupspaces 3 hours ago||
https://en.wikipedia.org/wiki/Royal_jelly#Epigenetic_effects
ck2 2 hours ago||
the Vitamin D cult is a bit insane

it is -exactly- like Linus Pauling and Vitamin C cult in the previous century

Vitamin D is very important

Too Much is as bad as Too Little

The "RDA" is too low at 600IU and should have been changed to 2000IU decades ago

It can help prevent certain diseases and illnesses

It CANNOT cure any known disease or illness once afllicted

ezekiel68 1 hour ago|
You kind of covered this in your last point but it's worth emphasizing: we generally don't know for sure whether "correcting" a low serum vitamin D reading helps out in some way or merely silences a warning beacon that should have been traced to a more serious underlying condition.
scythe 2 hours ago||
I guess I don't understand why this study is suddenly getting attention when these kinds of trials have been going on for years. This one doesn't seem to have a particularly strong methodology or particularly unusual findings. It's just another page in a very, very long record of evidence about vitamin D, and by no means settles any major controversy.
daniel_c_code 3 hours ago||
This is exactly what I've been thinking about lately. The modern knowledge-worker lifestyle is practically an experiment in extreme sun deprivation. We optimize our indoor spaces with perfect AC, ergonomic setups, and even custom ambient noise apps just to stay locked in a room for 10 hours a day doing deep work.

It makes you wonder how much of what we accept as "normal" afternoon brain fog or tech burnout is actually just our biology reacting to this massive behavioral shift and lack of natural light.

delecti 3 hours ago||
We also evolved to have activity levels that vary a lot more. A neolithic human wouldn't have done 8 hours straight of labor, or slept 8 straight hours at night. A few naps throughout the day would have been common, and sleep was often split in half as well.

It's one huge perk of working from home. Lying down for 20 minutes makes the rest of the day much more pleasant and productive.

kqr 3 hours ago|||
> afternoon brain fog

Check the CO2 levels in your office. They can get ridiculously high indoors when humans gather in the same room. It's not dangerous, but it makes people tired, they stop taking initiative, and less creative.

SoftTalker 3 hours ago|||
Myopia is one that comes to mind, with data suggesting that low exposure to natural sunlight contributes. Though in my case, I played outside a lot as a kid and I still have terrible eyesight.
stephc_int13 3 hours ago||
It is not about sunlight or UV. And it is not "just genetics".

The natural rest position of the human eye is to focus at the infinite. Focusing on closer objects like books or screens requires a constant effort (we don't feel it).

The eye simply adapts and elongate to relieve some of the strain. Wearing corrective lenses further amplify the process.

If you want your kids to have perfect vision they should spend a lot of time playing outside, until early adulthood.

ifwinterco 2 hours ago||
Yeah I'm not sure what currently "science" says, but from first principles something along these lines must be true, because "genetics" can't explain why some places like China went from low levels of myopia to extremely high levels in a couple of generations.

Clearly there's some significant environmental factor, and constantly focusing at short distances and/or getting no bright light exposure are the two obvious candidates (in other words, being inside all the time)

alexashka 2 hours ago|||
We share about 99% of our DNA with chimps.

Whatever we're doing that isn't what they're doing is not normal.

throwaway743 3 hours ago|||
Totally! iirc Germany implemented laws requiring sunlight exposure within offices so workers aren't deprived of it.
myth_drannon 3 hours ago|||
That's not recent knowledge worker problem. It started with industrial revolution and working 16 hours work days on a dark factory floor. What about Bedouins and other desert dwelling people? They had been trying to reduce sun exposure with complete body skin cover for millenias, it must have been some benefit for that. And what about skin cancer rates, it is probably reduced due to low sun exposure.
gnerd00 3 hours ago||
add night time lighting of all kinds..
rhtutjfkroi 3 hours ago|
[flagged]
giwook 3 hours ago||
> Pregnant person can do whatever they want with their body.

Yes, they can. But whatever they are doing to their body, they are doing to their baby as well.

Can they drink and smoke while they are pregnant? Sure, it is their choice.

Should they? Perhaps not, if they care about the welfare of the little human that is growing inside of them.

lloydatkinson 3 hours ago|||
Don't fall for it by replying; it's a troll, probably automated.
throe84jrjt 3 hours ago|||
[flagged]
lanfeust6 3 hours ago|||
I think this type of projection is problematic and regressive. Insights that research provides are a net positive.
lloydatkinson 3 hours ago||
Don't fall for it by replying; it's a troll, probably automated.
lloydatkinson 3 hours ago||
Before anyone gets in a stress, this is obviously some low life engagement bait troll. It might even be totally automated. It saw the word "pregnant" and decided to start on some diatribe about it without even reading the content of the link.

I am really sad that even HN is the target of this type of bullshit.

Waterluvian 3 hours ago||
I doubt it’s human. I suspect the goal is fomenting discord and making people burn calories on obvious garbage.