I guess you do it anyway? the change in the state of mind is thought to be at least in part the mechanism of action, no? so if thats what makes it work, its good to test it against a non hallucinogen

You can't, and it's a real problem for some people. Other people realize that, like testing the efficacy of parachutes by throwing two people off an airplane, one without a parachute; other people realize the double blind standard can't be applied but that the results aren't woo mystical astrology unfounded conclusions despite that.

It’s a single 100-microgram dose. It temporarily dampens the Default Mode Network (DMN), creating a "reset window" for the brain to rebuild its pathways. https://ir.definiumtx.com/news-events/press-releases/detail/...

I'm going to skip the line on this one.

Aldus Huxley was a proponent of LSD[0]. The Soma in his Brave New World is not meant to represent it.

[0] https://daily.jstor.org/when-aldous-huxley-dropped-acid/

Do other antidepressants, of which there are many, remind you of Soma as well?