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Posted by defrost 5 hours ago

For first time, a cell built from scratch grows and divides(www.quantamagazine.org)
https://biotic.org/research/spudcell/
525 points | 175 commentspage 2
bomewish 32 minutes ago|
The “from scratch” is doing a lot of work here!
FloorEgg 28 minutes ago|
I don't think I had ever heard the phrase "x is doing a lot of work here" until about a year ago, from Claude, which seems to say it's lot.

Out of curiosity, do you use Claude a lot and did you pick up the saying from it?

Are you Claude?

Or just a coincidence?

commieneko 1 hour ago||
Interesting. I pasted the article URL into Claude Opus 4.8, along with some questions about uses for cells that couldn't reproduce and Claude thought about it for a while, and then got murdered by the guardrails. I was invited to edit the question and try again; in a different chat. Or use a dumber model.

I suppose I can see why. But at the time I was just curious about the idea of "mule" cells.

dist-epoch 5 minutes ago||
Red blood cells can't reproduce and are "mule" cells - bags of hemoglobin. They are not really alive, so maybe not exactly what you were thinking of.
whycome 1 hour ago|||
What are the guardrails here?
commieneko 54 minutes ago|||
I've read than even a lot of high school biology questions can set off safety guardrails on Claude.
bellowsgulch 36 minutes ago|||
A lot of high school biology underpins the most immediate interesting aspects of chemistry and biology, and also the most volatile and dangerous ones.
libraryatnight 51 minutes ago|||
I'm curious what you asked? I had Opus 4.8 ingest the URL and give me some ideas about what's possible and it eventually got to AI and self repairing/improving factories along with listing risks etc.
commieneko 27 minutes ago||
Here's what I asked it:

"The idea of a cell that didn't reproduce at all occurred to me. Maybe created by a factory cell. It would be used to change an environment or produce some useful compound. I can imagine manufacturing them to process chemicals, or create mechanical structures. Put a network address in each one and they can be coordinated. The advantage of not reproducing is that they couldn't mutate if they had no reproduction mechanism at all. Can only come from the factory. Of course they could still be susceptible to viruses."

I've done a little googling since, and mule cells are actually a thing. In organisms they are very common. Neurons are an example. Parts of the immune system. There's also a thing in bacteria where cells divide, creating two daughter cells, one that can reproduce and one that can't. The one that can't makes a support structure around the one that can and then dies. This is how sporulation works.

None of this is deep, dark secret stuff. Some clumsy Wikipedia research got me this deep. If that's dangerous we are in deep sh*t.

(I'm not a biologist, I'm an animator who makes visualizations for university courses.)

IshKebab 49 minutes ago|||
They're paranoid about people using AI to synthesise anthrax or something. You also can't ask it how to build a nuclear bomb.
bradley13 51 minutes ago||
Which shows why guardrails on AI are just dumb. What harm could come from answering your question? None.
akomtu 15 minutes ago||
Scientists seem really busy these days creating synthetic life: advances in AI, human eggs from stem cells and now this - synthetic cells. I somehow feel they are inspired by the Alien movies.
mghackerlady 4 hours ago||
I wonder if these principles could be applied to non-organic components. I imagine a completely synthetic robo-cell would raise interesting questions.

Also, go MN!

small_model 4 hours ago||
The aliens that seeded life on Earth are seeing us making baby steps. Expect a visit soon!
JumpCrisscross 4 hours ago||
> aliens that seeded life on Earth are seeing us making baby steps

Or like a grad student didn’t dispose of their work properly and are desperately trying to distract from their scandal.

manIliketea 3 hours ago||
I vastly prefer the explanation like of Roadside Picnic. They didn't try to create us, they don't care that we're here, and, ultimately, we will never be able to know them in any meaningful sense. ;)
thriftwy 2 hours ago||
https://shkrobius.livejournal.com/401292.html offers a fascinating narrative rooted in cell biology
germandiago 3 hours ago|||
I never thought of it this way... who knows, could be a possibility! Oh, this is creepy...
kaizenite 2 hours ago||
There is a whole movie about it: https://www.youtube.com/watch?v=d1azwUwKrPo
aerodexis 3 hours ago|||
It's rare to see posts like this with such pure, crystalized ideology.
LogicFailsMe 3 hours ago||
Just wait 'til he finds out the alien was Trelane and he just wanted more soldiers for his play army.
r0m4n0 2 hours ago||
Or another take, life isn't all that special if we can make it this easily.

We have always theorized the start of life but this could actively show that life could have started on a rock floating in space given enough time. No sky daddy and no aliens necessary!

Tenoke 2 hours ago||
This is great, I assumed we were getting close (and not quite there), so it's great to see the progress. The path from here to building a single-celled organism out of nonlive materials looks very straight.
amai 1 hour ago||
The wikipedia website to "It's alive" (https://en.wikipedia.org/wiki/It's_Alive) lists mostly horror movies. So I'm not sure this is good news.
quux 3 hours ago||
Also discussed here: https://news.ycombinator.com/item?id=48747038
october8140 3 hours ago|
This is really cool. But I dislike the dialog where because step 1 happened people talk like steps 2-100 are not inevitable.
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