Top
Best
New

Posted by bohaska 8 hours ago

Melatonin impairs morning cognition in healthy young adults (2023)(academic.oup.com)
102 points | 57 commentspage 2
redrove 3 hours ago|
Could it just be dosage? Commonly found dosage is 10-20x what you'd actually secrete and IIRC absorption is actually quite good.
dripdry45 3 hours ago|
My understanding is that melatonin can overload certain receptors and cause an issue with fogginess since it works directly on the brain. 5HTP is more broad and is “gated“ on the same metabolic pathway, so cannot overload the system the way melatonin does.
JSR_FDED 2 hours ago||
My experience with Melatonin was very hit-or-miss. Sometimes it landed like a hammer and I was very groggy the next day. Sometimes it seemed not to work at all. This was with all sorts of doses.

I've found Tart Cherry - as an OTC supplement to work much better. More pleasant drift off to sleep, less waking up at night, and no morning grogginess.

rapsey 1 hour ago|
The body gets used to melatonin. It is actually a crap sleep supplement. It works worse every time you take it. What you should be doing is give the body the ingredients it needs to make its own melatonin like it is suppose to work.
karol 1 hour ago||
It just says that when you slept well you can be a bit drowsy.
RinatNabiev 1 hour ago||
Does this effect depend on dosage or timing? Would be curious to see the full study.
sublinear 1 hour ago||
> The results suggest that negative performance effects of exogenous melatonin may outweigh any benefits for healthy young adults

Not surprising at all. The vast majority of people taking supplements are avoiding either the doctor, eating a better diet, or regular exercise.

What are the odds that someone comfortable taking overpriced sketchy pills is also probably comfortable taking other substances? I only have to look at any random suburban strip mall in the USA to get my answer. I always chuckle at the IV drip place next door to the bar.

Uptrenda 3 hours ago||
As a long term insomniac the head line result is not surprising. My overall experience with "sleep aides" is they all lead to impairments in morning cognition. The worst of which don't last just the morning... (seroquel, I'm pointing at you...) Melatonin is surprisingly powerful for a hormone / supplement. For me, it hits like a truck, and I find it strong enough that I had to stop taking it.

I'd be careful with the methodology here. There's been research that shows that most melatonin supplements are megadosed, with something like the "physiological dosage range" being 1 - 2 micrograms (ug.) So I'd hope the researchers got a trustworthy source for their tablets. It seems to me that with such a low dosage range you don't have much margin to avoid errors.

I think when it comes to sleep problems the worst possible place to start is with pills. Pills quickly lead to dependence and a lot of them either stop working or introduce so many side effects that there's little "therapeutic benefit." I think the right approach for insomnia is to focus on improving overall health. A lot of symptoms people go to the doctor for in that category are due to life-style factors. So if you maintain healthy habits you don't have to end up on 10 different pills just to function...

It's a slippery slope, trust me on that.

margor 2 hours ago|
Yeah, sure.

I would love to find a natural or lifestyle remedy to common RLS or PLMD symptoms that I get from time to time. The problem is that for some people it's impossible to identify what are the triggers and sometimes it's just genetics you have no control over.

But sure, do tell people to avoid doctors and make them suffer even though there are drug remedies that don't cause dependence and augumentation.

maccard 11 minutes ago||
Being charitable to OP, I think their advice is to look after your health before hyper focusing on your sleep. I’ve had a similar experience - the better I care for my body the better my sleep is (and the opposite is a self reinforcing cycle). For me, personally, CBT and therapy helped hugely with the feelings of overwhelm I got from feeling like I wasn’t getting enough sleep and gave me the tools to deal with the fact that I’m not going to fall asleep at 11:30 and wake up at 7:30 like I would like to. It’s not perfect, but what is?
thin_carapace 2 hours ago||
melatonin should be consumed in doses an order of magnitude smaller than the smallest available dosage. melatonin should also be consumed in a particular time period to correctly trigger the circadian rhythm. long term consistent melatonin use is not advised outside of special cases (eg elderly where morning cognition is unimpactful). irregardless I don't believe that consuming modified release melatonin is healthy long term, because it breaks the circadian rhythm ... but if it works it works.

if you can afford expensive supplements, perhaps consider trying magnesium threonate for sleep. anecdotally this caused intense dreaming, leading to 1 less sleep cycle being required for restfulness. you could also try eating tons of tabouli and see if a massive apigenin hit calms the body for sleep. skullcap as a tea has some interesting properties regarding GABA modulation. on tea, passionflower is a decent MAO inhibitor and knocks some people out, but that's way less sustainable than melatonin. lastly dont lie down on your right side after eating!!!

eurleif 1 hour ago|
>melatonin should be consumed in doses an order of magnitude smaller than the smallest available dosage.

It's available on Amazon in doses as low as 100mcg: https://www.amazon.com/dp/B08MJL2GTC Are you saying this because you believe the correct dose is on the order of double-digit mcg, or because you're under the impression that the lowest available dose is single-digit mg?

thin_carapace 1 hour ago||
the lowest otc dose I previously witnessed was 1mg, perhaps my phrasing should have been "smallest commonly available dosage", because the correct dose is indeed around 100mcg
HexPhantom 1 hour ago||
[flagged]
janinarodriguez 7 hours ago|
[dead]