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Posted by brandonb 7 hours ago

Peppermint oil reduces blood pressure by 8.48 mmHg in small study(journals.plos.org)
69 points | 42 comments
jrflo 12 minutes ago|
Whenever I see a study like this I assume that the researchers won the p<0.05 lottery
Lu2025 1 minute ago||
Well, mint tea does make me sleepy
jeffnv 3 hours ago||
Noticing that the waist circumference on average went down on the peppermint group (85.17 -> 84.61) while the placebo group it went up (88.33 -> 88.65)? Also the resting heart rate dropped for the peppermint group. My initial suspicion is that the peppermint group coincidentally was also the 'got in better shape' group. Maybe the peppermint helped, but for relatively small groups that also seem to be improving waist circumference and heart rates likely due to good diet and exercise, I'm not convinced the peppermint did jack shit. More investigation needed! Would be awesome if it helped though!
vector_spaces 1 hour ago||
There has been some research on spearmint suggesting anti-androgen effects in PCOS, which is a bit unexpected to me as I wouldn't expect mint-family herbs to have much hormone modulating effect at all. I would imagine there to be similarities in profile between spearmint and peppermint so perhaps a related mechanism is involved, although I would probably expect the opposite outcome as a naive layperson. But I haven't closely evaluated the paper nor do I know whether there's been much else suggesting this

It is important to remember that herbs are difficult to study in this setting compared with isolated compounds -- likely because their pharmacological and chemical compositions are sensitive to many factors: hour and season of harvest, form consumed (raw powder, alcohol extract, cold water infusion, fat emulsion, hot water infusion, combustion, pyrolysis, essential oil), part consumed (leaf, root, flower, seed), among staggeringly many others. Anyone with experience consuming cannabis or coffee can probably testify to the above

Not to mention that the pharmacologically active compounds in many plants are far from being comprehensively understood, let alone their interactions and dynamics

This isn't to say that every claim about herbs is to be taken seriously. My point here is more that there is no good reason to dismiss the herb itself as a cause yet simply because it's an herb and a fairly mundane one at that. There are easy examples of herbs which have pronounced physiological effects, used for recreation, performance enhancement, as literal poison, to induce labor, to thin the blood -- among others.

https://pubmed.ncbi.nlm.nih.gov/19585478/

r0ze-at-hn 33 minutes ago|||
So spearmint is not peppermint. Peppermint (mentha pipereta in this study) inhibits CYP3A4 and CYP1A2. CYP1A2 is in the liver and if that is inhibited then estrogen will route down the CYP1B1 path so the ratio of the two metabolites 2-OHE1 v.s 4-OHE1 would be altered. For the PCOS (renamed to PMOS btw) if they start with elevated 2-OHE1 after the peppermint this could result in improve estrogen signaling because the now raised 4-OHE1 has much higher affinity than the 2-OHE1 for ESR1 (Era). ESR1 in particular is known for lowering blood pressure.

This particular path isn't that crazy, but it would only be for a subset of folk. From the study there is something simpler: menthol acts as a natural calcium-channel blocker, triggering vasodilation to reduce blood pressure.

mrob 1 hour ago|||
>I wouldn't expect mint-family herbs to have much hormone modulating effect at all

Mints are closely related to pennyroyal (Mentha pulegium), which was traditionally (and dangerously because of toxicity) used as an abortifacient. Its mechanism of action is still unknown, so hormone modulating effects seem plausible to me.

samudrijan 48 minutes ago|||
Sit and drink pennyroyal tea, I’m anemic royalty.
rshm 45 minutes ago|||
Also used as lactation reducing herb.
ktm5j 2 hours ago|||
But weight/mass didn't change one bit (okay exaggeration, but not by much), so maybe peppermint helps relieve gas. Who knows? There's a lot that this data could mean, and no simple way to figure it out.
ajb 40 minutes ago|||
It's actually prescribed for that: https://www.nhs.uk/medicines/peppermint-oil/
bherms 51 minutes ago|||
i actually had heard it helps w/ bloating/stomach issues online and took for a while and def noticed a debloating effect and less gas... obviously 1 anecdote, but I'd assume any slight waistline reduction is due to that. Also sidenote: pooping often made it feel like I put a breathmint... up... "there" lol
simondotau 57 seconds ago|||
Not surprising, it’s what happens to capsaicin too. Something has to happen to the molecules/compounds you consume. Either your body discards them, stores them, or transforms them.

The fascinating part is that your anal tissue has that level of sensitivity and insight.

samudrijan 48 minutes ago|||
Funniest thing today so far.
mlmonkey 1 hour ago|||
Peppermint oil has traditionally been used in India for digestion, so you may be on to something. I remember this particular brand growing up: https://www.amazon.com/clp/B001NQ7S9G (no relation).
f33d5173 1 hour ago|||
Nothing but blood pressure and heart rate was significant, and heart rate only barely so. I wouldn't read anything into the other numbers. It was a 20 day study, you aren't going to get long term outcomes from that.
potatoking 3 hours ago|||
I'd think weight could be causal for hypertension result or sentiment over health measurement could have been causal for weight or the study could just be too small.
criddell 1 hour ago||
When you say weight, do you really mean obesity? And if you are talking about weight, is it likely that people who live in low gravity environments will have fewer hypertension problems?
crooked-v 1 hour ago|||
Wild-ass guess: maybe the aftertaste of peppermint oil twice daily leaves people who are already unhealthy wanting to snack less, leading to minor weight loss.
rolisz 3 hours ago||
Maybe it helps with weight loss (I wish)
yumraj 2 hours ago||
It seems to aid in digestion, soothe upset stomach, so maybe it does.
reilly3000 12 minutes ago||
Aren’t people generally getting some via toothpaste?
yumraj 4 hours ago||
There are two types of peppermint supplements being sold: mentha pipereta that this study looked at, and mentha arvensis.

I wonder if mentha arvensis has the same effect. Supplements vs mint tea would be another interesting thing to study in future.

kzrdude 2 hours ago|
Based on your new information, I think it would be good to test the effect of supplemenths vs supplemints.
Palomides 2 hours ago||
HN really upvotes some dumb medical articles, come on, n=20 about peppermint?
binarymax 2 hours ago||
I've got an n=65 about hibiscus and blood pressure, which has been better well known for awhile. https://www.ars.usda.gov/news-events/news/research-news/2008...
spathi_fwiffo 1 hour ago||
now we need a study of adding Peppermint oil into hybiscus tea.
SwellJoe 52 minutes ago||
A Mediterranean place I used to eat at weekly served a hibiscus mint (spearmint, though) tea. Pretty nice.
rozap 2 hours ago|||
Silence, we have disruptive direct to consumer peptide startups that need to pump.
ChickeNES 1 hour ago|||
From PLOS One as well! I remember in college, I was taking a bio class that taught how to read journal articles...and a psych class that was assigning them. Psych class assigned almost solely PLOS One articles...which didn't survive the criticism I was being taught in the bio class lmao
pessimizer 1 hour ago||
If there's anything consistent about HN as long as I've been on it, it's that HN is orthorexic.
doublepg23 43 minutes ago||
> orthorexic

New word of the day!

catigula 50 minutes ago||
The funny thing is, I've read countless meta-analyses on various mainstream drugs, where total n=hundreds of thousands, and I still don't know if they work at all or not.
overtone1000 3 hours ago||
That is very accurate sphygmomanometry!
I_dream_of_Geni 3 hours ago|
I'm guessing that this number is the result of the average of "x" people in the study, and not an individual measurement. But, yeah, I see what that looks like.
techteach00 1 hour ago||
Also works well for IBS. Popular brand name green box. Bit pricey.
alastairr 3 hours ago|
Peppermint group N=20. Mkay. 2 of those lost to followup, one because they didn't like the taste (control group got peppermint cordial). The result might be real but needs followup before we all starting gulping down peppermint oil.
bryceacc 2 hours ago|
>50 µL of supplement diluted into 100 mL of water

pretty tiny amount of peppermint was consumed

HeyLaughingBoy 1 hour ago|||
I was surprised by this too. From a background in writing code to control precision pumps, I have a good idea of what 50 µL looks like and it seemed like an awfully small amount. But I don't know how concentrated the oil is.

FWIW, I had an Indian co-worker who took peppermint oil frequently and said that it was very good for his upset stomach.

jeffbee 2 hours ago|||
That's enough to turn a whole barrel of water detectably minty.
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