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Posted by sunnynagra 11 hours ago

FDA authorizes first wearable device that monitors ketone and blood sugar levels(www.fda.gov)
333 points | 161 commentspage 2
tiffanyh 9 hours ago|
I have to imagine Apple was pushing for similar functionality but probably got distracted over the last few years due to the lawsuits.
MBCook 9 hours ago|
Apple would want to make something non-invasive. I don’t think this is non-invasive. It looks a lot like the existing CGMs, but it does more.
chermi 8 hours ago||
How long has the tech existed to do this?
grahar64 10 hours ago||
Looked after my son who has T1D for now 5 years, checked keytones maybe 20 times. Compared to blood glucose which we check look at every 5 minutes.

Maybe this is more for Type 2 or other diabetes, or for people prone to DKA. Or it is for people with a working pancreas who think looking at their blood sugars (and now keytones) tells them something like soothsayers reading tea leaves

happyopossum 10 hours ago||
Considering that DKA accounts for 160k hospital admissions a year, your lived experience translates poorly to such a flippant dismissal.

[0] https://www.cdc.gov/diabetes/about/diabetic-ketoacidosis.htm...

jablongo 2 hours ago|||
In diabetics, DKA is preceded by hyperglycemia. Meaning, a CGM would tell you earlier that you are at risk for DKA than a CKM, a CKM would only tell you after you got it. Hence grahar64 is absolutely correct that as far as we know now, this provides no benefit to people at risk of DKA that a CGM does not already provide. I'm sure there will be some benefits but its really not clear at this point.
cogman10 9 hours ago||||
I agree, but there are a lot of factors going on to contribute to that number.

For example, about 20% of that number is because someone is finding out for the first time they have T1D [1].

Insulin costs and monitoring costs are also going to be a pretty big contributing factor. CGMs and finger sticks aren't cheap.

IDK how often it happens that ketoacidosis happens when glucose appears to be fine, I assume it's pretty rare.

[1] https://www.sciencedirect.com/science/article/pii/S016882272...

crisnoble 9 hours ago||||
A CGM that has ketone levels is quite literally pointless. If you have a CGM in the first place you would know if your sugars were high enough for long enough to get DKA.
badc0ffee 10 hours ago|||
DKA is what killed the legendary Dan Kaminsky.
cynicalsecurity 9 hours ago|||
Mate they won't understand. People generally are exceptionally ignorant about type 1 diabetes and also eager to fall for marketing gimmicks like this one. They have no idea what type 1 diabetes is.

For anyone who doesn't get it: glucose is checked every five minutes because it changes very often, jumping or falling dangerously. It's a nightmare. Checking glucose is 1000 times more important than ketones which are almost never a problem. If you get accurate glucose readings you are highly unlikely to ever experience ketoacidosis in the first place. Before ketones become a problem, glucose has to stay high for hours. Abbott is pulling this marketing trick instead of improving the quality of their sensors. Libre 2 is absolute crap. Libre 3 is somewhat okay and sometimes even mediocre - which is still a pretty bad situation. Bad glucose sensor is a nightmare and it can kill a person or a child much likely than ketoacidosis. It will actually lead to ketoacidosis by showing incorrect glucose readings. Now I wonder whether they added a ketone sensor as a failsafe for their low quality glucose sensors.

No one asked them to add a ketone sensor as an add-on to their glucose sensor, except maybe their marketing department. People want higher quality glucose sensors that fail less often and are more accurate. Glucose sensors, not ketones!

gluboy1 10 hours ago||
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ck2 11 hours ago||
bet marathoners and ultra runners will start using this to improve performance

(don't have a problem with that, but it's predictable)

too bad it's not "wearable" like a watch but that might be coming eventually too since Garmin has a patent on it

* https://the5krunner.com/2026/02/06/garmin-non-invasive-blood...

(btw Fenix 9 launched today but it's same hardware as Fenix 8 and no glucose feature)

crisnoble 9 hours ago||
Amateur cyclists already wear CGMs, and as a type 1 myself, they see mine and start asking all about CGMs. It must be so boring for them to worry about fluctuations between 85 and 120.
kccqzy 8 hours ago||
I don’t think amateur cyclists will have much to gain from this other than satisfying their curiosity.

Before buying one, just know that fit cyclists will appear glucose intolerant on a CGM. See Fig. 1 at https://pmc.ncbi.nlm.nih.gov/articles/PMC10933193/

mikestew 10 hours ago|||
There has been talk, but as one who hangs around those circles I've not heard of anyone actually doing it. But I'm sure someone is. At the same time, what I'm reading is that CGM won't give a non-diabetic any actionable information.
ijustlovemath 10 hours ago||
a regulated blood sugar level aids massively in cellular repair, inflammation reduction, and immune response. These are well studied and established. I could absolutely see a top athlete using AID in the future as part of a recovery routine, but I can also understand reluctance to adopt anything new or weird.
eoamk 9 hours ago||
A few years back, there were a number of startups that essentially resold prescriptions of the ABT/DXCM CGM and provided personalized meal/exercise-response analytics on top. Seems like traction has been tough going, though. Dialing back from "anyone with potential metabolic issues" -- what's a realistic market? Something like high-level athletes and/or bio-hacker enthusiasts are the only folks who seem to care. On the low end, the OTC options are eating away as well.. they are less accurate, but probably solve the use case better for a pre-diabetic "once-a-year/occasional" wear use case.

Talking to ultramarathoners and cyclists, I think lactate is a biomarker that is tracked (POC blood samples) and would be more immediately useful for training/performance. AID might be construed as a form of doping, IMO.

ijustlovemath 9 hours ago||
Lactate actually comes for free with blood glucose when you measure it with a chemical sensor, it's just not something that's usually asked for. I definitely think it would be considered a form of doping to use it in competition, but I think recovery is where it would make more impact anyways. You also wouldn't want to use it before a race, as you'd run the risk of reduced pancreatic function.

AGC will find its main application in surgical and inpatient uses, eg in cardiac, neuro, burn, ICU, and people with diabetes in any hospital setting.

mikestew 9 hours ago|||
I definitely think it would be considered a form of doping to use it in competition

Already banned:

https://www.bikeradar.com/news/uci-bans-supersapiens

eoamk 9 hours ago|||
There doesn't seem to be a continuous lactate sensor on the market. Lactic acid production and/or clearance are definitely useful data w.r.t. exercise (many training regimens talk about lactate thresholds) and also useful in in-patient settings.

No disagreement about AGC in the hospital -- there is a lot of lab/titration work in current clinical workflows for monitoring patient glucose levels.

ijustlovemath 9 hours ago|||
Lactate's available in the internal engineering data of these sensors, just not something that anyone has wanted to spend the time or money to qualify with the FDA. It essentially comes "for free" due to the chemical reaction the sensor uses.
eoamk 7 hours ago||
I think you are misinformed: the electrochemical reaction used by continuous glucose sensors relies on a glucose-specific enzyme and it doesn't have anything to do with lactate. Lactic acid strips use a completely separate enzyme/reaction.

Hat tip to you and sibling comment about continouous lactate sensors (seem like they are microneedle/patch based?). Quick review shows minimal clinical evidence, but maybe that's sufficient for the consumer wearable market.

ijustlovemath 7 hours ago||
I've had the fortune to work with several CGM OEMs behind the scenes as part of our work developing an artificial pancreas, they all have a secret lactate signal!
mikestew 9 hours ago|||
There doesn't seem to be a continuous lactate sensor on the market.

They exist, a simple search will turn up a variety (how well they work is a different question). But see my sibling comment, they're banned from cycling competition.

francisofascii 10 hours ago|||
I am curious how this will help. During training? During the actual race, the strategy is to eat a much as you can without puking.
anthomtb 9 hours ago||
I am aware of the "eating wins races" strategy for endurance sports.

Glucose and ketone monitoring seems a natural, more precise extension of that strategy. Isn't the point of carb-cramming to get more glucose into your blood stream, where your muscles can convert that into forward motion?

ordersofmag 9 hours ago||
Yes. But you don't need to monitor glucose levels to do this. Because it's well known you can productively use as much as you could manage to consume (without vomiting). So all the device will ever tell you (if you're in the middle of significant endurance event) is that you need to raise your blood sugar. It'd be no more actionable than a writing 'your blood sugar is low' on your hand with a sharpie.
loeg 10 hours ago||
> to improve performance

How? Like, what is the mechanism where this is useful?

flinner 9 hours ago||
Monitoring glucose and ketones can help you develop metabolic flexibility and let you grok how easily your body cuts over to ketones. Knowing your personal realtime glucose and ketone levels helps you understand just how much carbs will kick you out of ketosis or keep you in it. Glucose monitoring will help you avoid large crashes that can lead to low energy. Among other things!

More on metabolic flexibility: https://www.levels.com/blog/what-is-metabolic-flexibility-an...

loeg 9 hours ago|||
My understanding is that essentially all high-level endurance athletes are just maximizing their simple sugar intake at all times (during exercise) and knowing blood glucose/ketone levels wouldn't change anything about that intake, nor would it have any impact on crashes.
ifwinterco 9 hours ago|||
All high level endurance athletes are on high carb diets all the time and are never anywhere near ketosis (unless something has gone very wrong)
petesergeant 10 hours ago||
I thought this was going to be a non-invasive sugar-level device, but it looks like in fact the innovation here is that a popular CGM line can now do ketones?
ijustlovemath 10 hours ago||
non-invasive continuous blood sugar measurement is mired in patents and technical challenges. Turns out it's really difficult to disambiguate the absorption lines of glucose from other similarly shaped molecules when you're also dealing with untangling skin conductivity, transmissivity, sweat, inflammation etc.
johen8 10 hours ago||
I also think there's no financial incentive from incumbents to develop something like this. Why would abbott develop something that works "forever" if they can milk people buying new sensors every 10~14 days.
cogman10 10 hours ago||
For abbott, no. But what about for Garmin, Apple, Samsung, or Google?

Diabetics would snap up a smart watch which does accurate glucose monitoring in a heartbeat.

ijustlovemath 10 hours ago|||
There is a major IP holder in the space who is asserting their ownership, so even if they could solve the technical challenges, they might not be able to come to market.
nomel 9 hours ago||
> There is a major IP holder in the space who is asserting their ownership,

Is it a secret? Why not name them?

petepete 9 hours ago|||
As a T1 diabetic, can confirm.
jakefromstatecs 10 hours ago||
Seems to be the case, yeah
itsryanlenk 4 hours ago||
so weird this is at the top. I just wrote an article yesterday about zuck and the masterclass that the meta ray-ban glasses are.

Wearables ain't going anywhere but up.

batisteo 9 hours ago||
Reminds me of this warning: https://youtu.be/S6Jiei4Wup4 (Youtube Short from the Drey Dossier)
Parker_Fawcett 4 hours ago||
Is it trustable?
cat-whisperer 8 hours ago||
science is awesome
cynicalsecurity 9 hours ago|
As someone who has to deal with type 1 diabetes every day, this is marketing nonsense. No one needs ketones in the sensor - we need high-quality sensors, and Abbott's are only mediocre at best. They are not as bad as Dexcom, which is appalling, but they are still far from the superior quality of Medtronic/MiniMed which measure glucose exceptionally well.

Ketones are rare. They can kill you, but before that happens, your blood sugar usually rises enough for you to realise you may have ketones and start using test strips to measure them. Instead of this marketing gimmick, Abbott should have focused on improving the quality of their glucose sensors which is far more important.

lolc 8 hours ago||
I tend to agree that making the sugar measurements more robust is worth more than measuring the ketones at all. However, low sugar and high ketones can happen. And just getting notified when ketones pick up can be worth something too. The additional measurement is not useless seen from my perspective.

As an example: I was on a study that gave T1D patients Dapagliflozin (Farxiga). During the study, while on a long hike, I was hovering at low sugar and consequently insulin supply was mostly cut off for an extended period. As I started to to feel unwell, I measured ketones. I was briefed as preparation for the study to measure ketones when something seems wrong. Otherwise I wouldn't have thought of measuring ketones. Might not even have carried the kit.

On that occasion, the ketones were way above 1 mmol/l: a very high value. Protocol would have required me to call the study doctor due to the high level. Since it was a Sunday, I spared her, shot some insulin, ate a sandwich, and continued my hike. I could do that because I was not alone on that hike. I knew that if my situation deteriorated, somebody would be around to call rescue.

At the study debriefing I mentioned the incident and they said that adding to the effect of the Dapa, I was probably dehydrated, which led to the rare situation of both low sugar and high ketones.

All in all I think that if the sensor makers exhaust possible improvements for the glucose, it can make sense to add the ketone measurement as a safeguard. Having high sugar can have many reasons, and it often takes me a while to get to measuring ketones. Getting the signal of rising ketones, I would react faster a few times a year in situations where my insulin supply is broken.

croemer 7 hours ago||
What's so bad about Dexcom and Freestyle compared to Medtronic CGMs?
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