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Posted by artninja1988 2 days ago

The Millennium Problems for Biology(millenniumproblems.bio)
160 points | 119 commentspage 3
the__alchemist 2 days ago|
It has not escaped my notice that a significant portion of these are of the form "Design a protein that..."
pixl97 2 days ago||
It turns out that proteins are responsible for a whole lot of different things in biology.
ehe78qhe 2 days ago||
https://xkcd.com/3056
magistra 1 day ago||
why curing cancer or HIV is not at included at The Millennium Problems?
Protostome 2 days ago||
AI slop. next.

Edit: A true expert would never define a problem in such a sloppy way: "Specifically, the protein must convert N₂ to ammonia at rates that are at least of a similar order of magnitude to the rates of naturally occurring proteins, and must fall well below the sequence- and structure-similarity thresholds relative to all known nitrogenase and nitrogenase-like proteins. The protein may be designed de novo, discovered in nature, or engineered or evolved from naturally occurring starting points."

xybuller 2 days ago||
There is a curious lack of small molecules or biocatalysis in this list
Haunt1000 2 days ago||
You'd think halting or reversing aging would be on this list...
xybuller 2 days ago||
List is missing small molecules and biocatalysis
yewenjie 2 days ago||
Who is this by? Who verifies the result? Is there prize money?
fragmede 2 days ago|
On the page, it says

EDISON SCIENTIFIC · FUTUREHOUSE

SAM RODRIQUES · MICHAELA HINKS

https://edisonscientific.com/team

Q6T46nT668w6i3m 2 days ago||
It’s strange they are all engineering problems.
HarHarVeryFunny 2 days ago||
What would be your idea of a biology problem that isn't an "engineering" one?

It seems that understanding biology could be characterized as trying to figure out "how did nature engineer this".

For that matter isn't all of science this way?

zhaoziyuan2000 2 days ago|||
There are certainly non engineering problems out there... For one example, in biomedicine it's known cancer in different organs can have preference of having immune hot (in skin and lung cancer, e.g.) and cold tumors (in pancreatic and prostate cancer, e.g.), and current immunotherapy work much less well on the latter. Why this pattern exists is still an open question very important for treating patients and it's not a how did nature engineer question as it's a unintended byproduct from several tiers of complex biology involving understanding mutational burden in tumor cells, immune surveillance surrounding the tumors, and mechanical structure of the tissue, etc. The engineering payoff comes later, i.e., immunotherapy works better on a particular subset of patients, after explaining and understanding the biological phenomenon first.
dnautics 2 days ago|||
Chemiosmotic effect
HarHarVeryFunny 2 days ago||
What aspect of that is an unsolved problem, and one that feels more fundamental rather than engineering / in need of explanation ?
dnautics 2 days ago||
Its not unsolved. It's very solved. It was not an engineering question.
HarHarVeryFunny 2 days ago||
It seems that physics -> chemistry -> biology is a layering of abstractions and/or emergent phenomena, and any explanations of mechanics at these higher levels is more along the lines of "how was this built from these lego blocks" rather than being some more fundamental discovery.

You keep on making assertions - perhaps you could back it up with some explanation of why you regard this as a more fundamental discovery (or however you would like to characterize it)?

dnautics 2 days ago||
"how was this built from these lego blocks"

That is not engineering. Nobody would call astronomy or cosmology engineering and it is very much the study of "how the universe is built from some basic building blocks.

Don't assign a reductive meaning to engineering that is so encompassing that everything everywhere is engineering, else you render "engineering" a meaningless concept

analog31 2 days ago|||
In a sense all experimental science has an element of engineering. For instance the first problem, "the origins of life" is framed to require an experiment to show that any proposed mechanism actually works.
ClaraForm 2 days ago|||
Right? Where's the substrates of consciousness, or the actual solutions for protein/rna folding, or the requirements for evolution?
randomImmigrant 1 day ago|||
Substrates of consciousness… I think they don’t have it here because they can’t come up with an answer a bunch of AI models will find. Certainly a Millenium problem for biology if there ever was one.
anon48293 2 days ago|||
Substrates of consciousness? You mean the neural correlates of consciousness which we already have?
ClaraForm 2 days ago||
As a neuroscientist: no. Not what I mean.
anon48293 1 day ago||
Then please enlighten me. What else do you want except what neural activity is necessary and sufficient for a conscious experience?
kolinko 2 days ago||
What else?
randomImmigrant 2 days ago||
Eh. Some of these are genuinely interesting problems. Others like cryopreservation and Protein amplification chain reaction are scientifically close to nonsensical.

Rodriques is CEO of Edison scientific, which is going all in on agentic biology. These problems are all benchmarkable, and have been selected to allow for agentic exploration. That is, the tool is driving the problem selection more than genuine value to the field in solving these problems.

Still, if someone takes any of this up and manages something, it’ll be cool.

dannykwells 2 days ago|
Bingo.
cupantae 2 days ago|
Slap an LLM on those and call it a day
alansaber 2 days ago|
Need to scrape the logs from some leading researchers first
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