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Posted by raahelb 5 hours ago

Claude discovers a novel enzyme system with CRISPR-like repeats(www.anthropic.com)
376 points | 381 commentspage 3
6thbit 3 hours ago|
when they say "claude" what model do they mean ?

no mention of opus/mythos/fable or anything..

sigmar 2 hours ago||
seems like mythos 5 did most of the leg work, they refer to it in the technical report linked at the end: https://www-cdn.anthropic.com/22573675ada52a8ca8a97a1a4b4326...
6thbit 2 hours ago||
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m00x 3 hours ago||
It could be an internal model as well.
dawnerd 3 hours ago||
Could also just be hired specialists internally and it's pure marketing (even if they discovered something new).
6thbit 2 hours ago||
lol, it's true, Claude in the article is so anthropomorphized that you could read it as if it was a human just as well.
cactusplant7374 2 hours ago||
Was he paid to review the paper? His praise reads very unauthentic.

> After reviewing the pre-print, Feng Zhang, one of the pioneers of CRISPR genome editing and a professor at MIT and the Broad Institute said:

> This is an exciting example of how AI agents can contribute to biological discovery. The identification of RNA-repeat arrays associated with reverse transcriptases is genuinely intriguing and merits further investigation. I hope this work encourages more scientists to explore how AI can support their research.

MachineMan 4 hours ago||
Don't use it for biology, Dario said, as he turned humans into Teenage Mutant Ninja Turtles.. I reckon that soon, he too will return to dimension X.
hackeraccount 3 hours ago|
I call Michelangelo!
mullingitover 4 hours ago||
This is great, but I can't help but wonder if we're going to have another post next week with a lab complaining that they were about to publish this same finding, and they had Claude proofread their paper, and whoops how'd that get into Anthropic's training data?
monospacegames 4 hours ago||
I wonder how long it will take for the damage Alpöge and Buckmaster have done to the perception of these AI-driven scientific developments to fade.

Not saying that they were right or wrong, but that single moment sullied all AI-driven breakthroughs that came after it, and I don't think it was ever particularly relevant, at least not nearly to the degree that it was presented in the media. But I guess it ended up being a convenient outlet for AI anxiety in the end.

mullingitover 3 hours ago|||
I don't think of this stuff in terms of AI anxiety, I just think that the AI labs should be falling all over themselves to display deference and humility to those who made it possible.

The LLMs that make this stuff possible weren't created by the AI labs from whole cloth. They crept up and jumped onto the shoulders of giants, basically the collected (non-consensually, of course, but jingles keys look at this pelican riding a bicycle!) works of humanity. Every discovery LLMs enumerate in this fashion rightfully needs to have a billboard-sized asterisk regarding the provenance of the discovery. "Claude" didn't discover this, everyone who worked to produce the internet that Anthropic siphoned into their dataset belongs on the credits.

It's great that it happened, and I wish them the best of luck in using our work to make the world a better place. Just don't forget who the rightful owners are.

techpression 3 hours ago|||
The AI labs did that to themselves. All those billions and their marketing and communication skills are like those of a local street vendor selling fake knockoffs.
epistasis 4 hours ago|||
This is a very inaccurate manipulation of facts that fundamentally misrepresents everything that mathematicians wrote.
bananaflag 4 hours ago|||
Shouldnt this be "misrepresents"?
thorum 4 hours ago|||
In what way?
petcat 4 hours ago|||
Lots of stuff gets discovered by AI bots that was always hidden in plain sight. They're remarkably good at "connecting the dots".
pixl97 4 hours ago||
Being an effective pattern matcher and next word predictor is like 60%+ of intelligence, maybe more.

The people that say "It's just a next word predictor" might as well be saying "Well, it's just a long rage nuclear missile".

jjtheblunt 4 hours ago|||
the article says the reverse transcriptase had been noticed before, but apparently only Claude commented on the subsequence repeating, to your point.
caaqil 4 hours ago||
[flagged]
Chance-Device 4 hours ago||
I think this approach of actually doing useful science is better PR than hiring an army of influencers to shill for you, OpenAI style.

Generally speaking, hiring an army of influencers to shill for you results in bad PR, and comments like this one.

the__alchemist 4 hours ago||
It's not useful science; it has the rigor of someone posting a vague shower thought on Show HN or reddit.
ethanj8011 1 hour ago||
I'm not going to say that it is absolutely Earth shattering (not that they claim that), but your comment is obviously wrong. In the paper they show experimental results where they express some of the proteins and show a phenotypic effect. They don't claim an exact function either, and are relatively restrained on the biology end of things. I fail to see how it is at the level of a vague shower thought.
the__alchemist 52 minutes ago||
> Although we don’t yet know its function, the system that Claude discovered has a set of characteristics that have only ever been found together in a handful of other systems, all of which are programmable and perform operations like cutting, copying, and pasting DNA. Beyond CRISPR, which has already transformed science and medicine, several other such systems are now in development as promising tools.

It's not novel, and they don't know if it means anything. They published it here for PR purposes.

binlog 3 hours ago||
You really think there aren’t an equal number of Claude influencers on social media?
Chance-Device 3 hours ago|||
Yes, I think there aren’t an equivalent number of Claude influencers on social media.

Is there an equivalent headline for Anthropic of this?: https://www.businessinsider.com/inside-open-ai-influencer-ma...

binlog 3 hours ago||
Takes 2 minutes to search for news beyond the HN front page - https://www.cnbc.com/2026/02/06/google-microsoft-pay-creator... https://www.inc.com/georgia-fearn/openai-anthropic-both-cour...

https://www.businessinsider.com/emma-orhun-canceled-claude-p...

> Anthropic’s head of influencer, Lexie Barnhorn, has described creators as essential to building trust in complicated technical products. Its strategy is partly consumer-to-business: People who adopt Claude personally may later introduce it in their workplaces.

> Anthropic’s best-known creator events have been smaller dinners and pop-ups in which Claude remained the ostensible subject.

Chance-Device 2 hours ago||
The point I am making is if these companies are going to compete and spend more and more money for PR, then they should do it in a way that benefits society, which paying influencers does not do.

Let me know when OpenAI starts actively trying to cure diseases.

foxrider 3 hours ago|||
Personally I feel like Anthropic is underrepresented in "normie" marketing, all of my non-tech savy friends only know of ChatGPT and use "ChatGPT" in the same way my mom says "Nintendo" when talking about game consoles
binlog 3 hours ago||
On the other hand Anthropic has a monopoly on the vibe coder/tech influencer/“podcast bro” market. Claude has been pushed very hard in that ecosystem.
contemporary343 2 hours ago||
I'm sorry but this would be a mediocre paper at best. And if this were a student presenting this for a qualifying exam, you can bet a committee would be ripping them a new one for presenting this with no understanding of what it does.
gehsty 1 hour ago|
It’s a blog post about work an LLM did though?

The pre print clearly states it’s a well defined problem limited by the man hours required to sift through the data. I think everyone knows it’s not setting the world alight?

lossolo 3 hours ago||
> Anthropic sets up Bay Area lab beyond computer simulation work, two sources say

> Startup aims for Claude AI to direct robots in lab environments, one source says

> Company to stop short of clinical trials to avoid drugmaker competition, life sciences head says

https://www.reuters.com/world/anthropic-quietly-sets-up-biol...

doctorpangloss 4 hours ago||
Aren't there unlimited mechanisms like this? Isn't this why Doudna isn't a billionaire (you can patent something, but it's easy to create another one and patent it separately)?
nonameiguess 3 hours ago||
I wish we could discuss this in a way that didn't immediately devolve into people shouting up or shouting down that this is either meaningless or singularity.

Caveating I'm not a biologist, but my understanding of the way this kind of thing works right now is a basic three-step process:

1) Find molecules and DNA/RNA sequences in the wild and catalog them.

2) Discover interesting subsequences among these.

3) Figure out whether any useful applications can come from what was discovered.

All three of these generally take a long time. Systematic automatic analysis of known databases speeds up and removes some of the luck from 2. But 1 and 3 are still long poles. 1 has the further issue that we usually discover these in existing organisms. I recall much of the outcry over tropical deforestation back in the 90s and replacing of rainforests with palm oil monoculture today is that the vast majority of terrestrial biodiversity is found in rainforests, and destroying them at industrial scale risks losing potentially useful molecules forever. 3 has the problem that you need to conduct physical experiments, and are limited by the speed of biochemical reactions no matter what and by the speed at which human subjects can be found and ethically experimented on assuming we care about being ethical.

A lot of good can come of this, but I don't see a path to singularity here, assuming we're talking the original Kurzweil meaning there of all technological progress that will ever happen all happening at once. Data collection and experimentation on living subjects, human or not, can only happen so fast, regardless of automation. It's not computational. Whenever you have to interface with the real world, you're now working at the speed of the real world, not the speed of electricity. CRISPR was discovered in 1987 and first used to edit a gene sequence in a human zygote in 2015. I'm sure there are plenty of ways to make the candidate discovery to human application step not take three decades, but it's never going to be three months, either.

evolarjun 15 minutes ago|
I agree, this is a cool result, but not something far out or extremely novel. It's discovering a new class of things that is different from other similar things we already knew about. One of those similar things we already knew about (CRISPER) turned out to be better than other tools we have for editing DNA in vivo, so that makes it potentially more exciting, but others haven't had the same application. It's interesting because the function is unknown, and you're right there's a lot of followup to figure out just exactly what is going on and why, much less to come up with an idea for how to use it to do something cool.

To me this strikes me as an incremental discovery that would have taken someone with time, interest, and expertise to make before. It could have cool applications or it could just be interesting biology. Molecular biology has progressed through many years and many rounds of automation and new tools, but the problems are still hard. This just strikes me as one more way we may be able to speed up one part of the process.

guideaitools 2 hours ago|
[flagged]
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