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Posted by raahelb 6 hours ago

Claude discovers a novel enzyme system with CRISPR-like repeats(www.anthropic.com)
451 points | 498 commentspage 5
iamronaldo 6 hours ago|
[flagged]
jrflo 6 hours ago||
From the article:

> All of the lab work is performed by human scientists.

eleventen 6 hours ago|||
That doesn't mean the humans aren't meat puppets.
jrflo 5 hours ago|||
I think the odds of a human accidentally creating a novel virus or bioweapon at the behest of a rouge AI are pretty small to be honest. That's a lot of manual labor to go "oops I didn't realize what this was!"
eleventen 3 hours ago||
In the short term you're probably right. But after a couple of years, complacency will take over and more and more decision making will get ofloaded. I don't think it's out of the question before 2030.
guy4261 5 hours ago||||
I just realized how great it is that this term became great again. https://en.wikipedia.org/wiki/Meat_Puppets
unglaublich 5 hours ago|||
Are we anything else? Our complete behavior is shaped by our upbringing, media exposure, education. "Do we even have free will?"
MeditatingMarmo 5 hours ago||
No, but it also doesn’t make any difference, I think.
looperhacks 6 hours ago||||
Not that I agree with the comment you're replying to - but I find this response funny, when just today there was a link on the front page about the US military bombing a school because of AI output
phoghed 5 hours ago||
That you clearly only read the headline of
bpodgursky 5 hours ago|||
Biosafety is a very real concern but "lab" is a big bucket, a molecular genetics lab can't synthesize new viruses out of thin air if it's not a virology lab. Sequencers sequence etc. The lab has the equipment it has.
datadrivenangel 5 hours ago||
It's okay, fable will not help them with any dangerous biology work...
catigula 5 hours ago||
This work seems directly dangerous to me?
evolarjun 4 hours ago||
The study results themselves aren't really dangerous in any way I can see. This is basic microbiology, and not necessarily some kind of major breakthrough that will change the world on its own. It's possible this leads to something big like CRISPR, but most likely not. The work is more the case of noticing something that someone hasn't noticed yet. It would have gotten noticed eventually, they just did it before someone else did (assuming they didn't get a hint somehow).

A lot of molecular biology is noticing something that you can't explain or that seems weird and might be interesting. Once it's noticed the followup is often fairly straightforward and it either pans out or it doesn't. The exciting/scary/unlikely part is that the LLM on its own recognized something as being important to follow up.

From my skim of the paper, the work could only be done by someone with a pretty good understanding of the biology and an extremely good understanding of how to use LLMs and agents. LLMs are not going to take over biology yet.

catigula 4 hours ago||
You don’t see a problem with LLMs in wet labs doing biology work?
nozzlegear 5 hours ago||
Just wait until Anthropic opens up their wetlab!
irregularbowels 1 hour ago||
[dead]
eqmvii 6 hours ago||
In a year or two, articles like this will either be artifacts from peak hype or evidence of the beginning of the singularity. Right?
pizza234 6 hours ago||
The singularity, as defined by Hinton (and others) as RSI (Recursive Self Improvement) may actually be beginning already, as OpenAI has announced an AI acting as a "research intern" (!).
jackb4040 5 hours ago|||
How is this different from arguing that Microsoft Clippy was RSI? An AI tool being involved in the process of work can't be the bar for RSI.

I don't think there can be a coherent definition of RSI unless people lay out their theory for how intelligence scales. LLM-assisted coding is great but respectfully optimizing pytorch features or whatever is not gonna lead to exponential improvements. That approach to scaling diminished years ago, leading all the labs to switch to reasoning.

Now it seems reasoning is also yielding diminishing returns, so all the labs are pivoting to specializing in particular fields like math / infosec / biology. They're improving due to accessing new proprietary training data and doing RL with human experts. Again I don't really see any amount of "AI research interns" leading to an exponential improvement to this strategy, they're not the bottleneck in the first place.

famouswaffles 1 hour ago|||
>Now it seems reasoning is also yielding diminishing returns

Is the diminishing returns in the room with us?

>so all the labs are pivoting to specializing in particular fields like math / infosec / biology.

They're not pivoting to anything. The goal has always been creating a machine that could automate all or nearly all human work. They're just coming along on that mission.

As for RSI...I think the term is a bit odd in the modern context. It was created at a time when conventional wisdom was that generally intelligent machines would be these logic automatons that could "alter their own code". Instead we have massive neural networks that take months to train.

In this paradigm, the ways a LLM could "improve itself" would be altering its own weights directly or creating and training better, vastly more efficient architectures for the next generation of models.

The former is probably not happening but the latter is possible.

jackb4040 1 hour ago||
Yes, diminishing returns. Not overall, they've still been able to create more intelligent models even up to today. But the strategy for scaling that intelligence has shifted. From the initial ChatGPT release to GPT-4.1, they were basically scaling up compute training compute / model size. Then 4.5 flopped, while o1 demonstrated that gains could continue by reasoning (scaling up compute at inference time). o1 is now the ancestor of all their flagship models from GPT-5 on.

This is why I'm trying so hard to drill down on the theory of scaling, and not just talk about improvement in general, hand-wavy terms. If the bottleneck of current scaling strategies is training data, or something fundamental about the model architecture, then just throwing more harnessed chatbots at it won't lead to an exponential increase in performance.

Now you could argue that the AI we have now will help us find that change in architecture, and I would agree. But that means we're firmly outside the singularity for the time being, and what people are in fact talking about is a hypothetical.

famouswaffles 1 hour ago||
>Then 4.5 flopped, while o1 demonstrated that gains could continue by reasoning (scaling up compute at inference time). o1 is now the ancestor of all their flagship models from GPT-5 on.

That's not quite right. They are still scaling model size and have had several new base pre-trains, just nothing so big as 4.5 (as far as we're aware). o1/4o has not been the base for some time now.

Data is obviously a bottleneck for some regimes and LLMs will have to get their hands dirty experimenting but it doesn't look like an insurmountable wall either.

pizza234 4 hours ago|||
> Now it seems reasoning is also yielding diminishing returns

Not true. On the contrary, LLMs are developing faster than predicted. They were expected to solve a Millennium Prize by 2030... and here we are in 2026. Release cycles are getting faster. Just compare the most recent GPT or Claude with what they were an year ago.

> How is this different from arguing that Microsoft Clippy was RSI?

We can argue about semantics, but that's not really the point. The point is that what started now - which no doubt is in its infancy - will result in full autonomy quite soon (they project an year or so), with the risk of RSI causing agent development to slip (long term) outside human cognitive control/capacity.

jackb4040 4 hours ago||
Again, can you lay out your theory for how intelligence scales? You're using a lot of terms like "full autonomy" without definitions. Why do you think that just throwing more harnessed LLMs at (something?) will lead to an increase rate of improvement?

I feel like I laid out several cases where other things were the limiting factor on improvement and more agents wouldn't have helped, and I didn't get a response to those cases.

What "they project" (the labs) is of minor interest to me. Aside from their incentives and track record of lying, in recent months they are laying out a story that is pretty much just the plot of Terminator, and directly referencing rationalist beliefs that were published long before LLMs even existed.

physicallyIllfr 5 hours ago|||
How is it improving, that would require rearranging its weights and biases which it cannot do easily or quickly.
pixl97 5 hours ago|||
Self improvement during training, and AI self training are already happening. Easily/quickly are seemingly a factor of how much power/hardware you want to use at once.

With the level of compute they have they aren't stuck with frozen models like you are.

criddell 5 hours ago|||
Is easily and quickly a requirement? Isn't it enough that over time it improves itself even if the process is complex and slow?
nozzlegear 4 hours ago||
Do we know it's actually improving itself? Perhaps it's just opaquely sorting all ones and zeros for better lookup efficiency.
BobbyJo 6 hours ago|||
Yes. I would bet on the latter.
dude250711 6 hours ago||
That's black and white thinking; it will be a midgularity - so neither.
kikokikokiko 5 hours ago||
Mehgularity
demritocracy 5 hours ago||
Whompageddon
hn_submit 5 hours ago||
Fake news to pump up their share price. You can't trust any news about A.I. these days, especially near their IPOs.

This A.I. hype makes the Internet Bubble look like a walk in the park.

yehudalouis 3 hours ago||
Why is it fake news, and how do you know that?
stevenhuang 3 hours ago||
If by now you still think it's all just hype, it's safe to say you've succumbed to a mind virus that renders you unable to think critically about AI. Otherwise you'd have some level of awareness of just how far this technology has developed, and you should find these developments more than plausible.