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Posted by benbreen 1 day ago

The technology to eradicate mosquito-borne disease exists(worksinprogress.co)
219 points | 175 commentspage 2
Arubis 5 hours ago|
Something about mosquito-borne diseases lands on HN every year or so, resulting in hand-wringing about whether we should deliberately cause species extinction. I have seen the suffering they cause firsthand, and so my response has become rather consistent:

Do we want to eradicate mosquitoes?

Yes; fuck them.

We (intentionally or no, mostly not) cause the extinction of hundreds to thousands of species every year for much more mundane reasons: deforestation is the big one, climate change another. And that buys us arguably nothing but enriching people that benefit from the process of deforestation and climate change--folks that're economically desperate enough to log illegally, and energy barons. These extinctions are mostly tragic, and the net benefit to human societies is likely negative.

Mosquitoes are fucking evil. They kill more humans every year than any other animal. Malaria is only the most well-known disease they spread; see also dengue ("breakbone fever", named for what it feels like), West Nile virus, and more. Those that malaria doesn't kill are frequently left with a low-level chronic infection that makes them less effective as people. Malaria and mosquitoes kill children, disable the working population, and economically cripple entire nations.

As best we can tell, things that eat mosquitoes also eat other things. But I'd vote for nuking the mozzies from orbit even if that weren't the case. They're such an unmitigated cause of human suffering and hardship.

bamboozled 1 hour ago|
Mosquitoes are fucking evil.

They're not evil, they have zero idea about the consequences of their actions. I think this viewpoint is why people are hesitant to just make things go instinct because people don't like them. Yes there might be good scientific / humanitarian reasons for it, but mosquitoes "being evil" isn't one of them.

jms703 4 hours ago||
How does this affect fish that eat mosquitos like trout? Do they have enough food without mosquitos? Just wondering.
BugsJustFindMe 2 hours ago|
YSK, there are like 4000 species of mosquito and this is talking about getting rid of only a small number of them. There would still be lots of mosquitoes.
moralestapia 1 hour ago||
Great article, I really like the writing style as well.

Anyone knows more about the author? The info there is a bit scant and I'd like to read more from her.

I found one Maya Rosen online[1] but she seems to be devoted to Jewish texts, Judaism, and all that. Does not seem related to this, but it might be her?

1: https://jewishlearningcollab.org/educator-bio/?id=272

kubanczyk 7 hours ago||
Humanity is eradicating entire species left and right. Mosquitoes are our worst enemies. Can we have a deal to save some little poor amazonian frog (the doomed one which has only ~100 animals and 1 location left) and after we accomplish that, in return wipe out one species of mosquitoes?
Arodex 7 hours ago|
I hope the Amazonian frog doesn't depend too much on mosquitos as food. Or that by eradicating mosquitoes, insectivorous animals don't eat more of other, less abundant and fast-breeding, insects as a replacement and it starved the Amazonian frog.

(I don't know what the Amazonian frog eats; my point is that biotopes are complex and second- and third-order effects need to be monitored. That's why smaller interventions - e.g. making humans poisonous to mosquitoes, pushing them to the evolutionary path of avoiding humans - would be better than whole eradication.)

OneDeuxTriSeiGo 2 hours ago|||
Note that these specific mosquito species are invasive in most of the world after they escaped their native ecosystems and proceeded to spread like wildfire so arguably eradicating them would be a net benefit for most ecosystems.
lostdog 6 hours ago|||
Human-biting mosquitoes aren't necessary for the ecosystem and we should remove them.
Arodex 3 hours ago|||
https://www.orkin.com/pests/mosquitoes/what-eats-mosquitoes
andrewflnr 2 hours ago||
What part of that requires that they specifically be the human-biting ones?
someonebaggy 5 hours ago|||
That's what we thought about all the other species we intentionally eradicated, both the ones that turned out to be unimportant, and the ones that turned out to be very important.
voxleone 4 hours ago||
In certain parts of the world an entire lifestyle has been built on the logistics of the old pesticide methods. Good luck getting rid of them. Furthermore, and this matters enormously, Walbachia is still a nuisance. If Walbachia replacement is deployed, a resident can quite reasonably say: “Great, dengue risk is lower, but why am I still getting eaten alive in my backyard?”. That resident may continue demanding spraying, larvicides, traps, pest control, etc.
lmz 3 hours ago|
I thought only male Wolbachia-infected mosquitoes were released, and only females bite?

Larvicides can still be a thing though. No benefit in keeping those around.

Tangurena2 2 hours ago||
The female mosquito (like female bedbugs) does the biting to provide food/energy to make the eggs she lays.

She mates only once, which is why releasing sterile males works to reduce mosquito populations.

https://www.rockefeller.edu/news/38495-what-we-got-wrong-abo...

the paper:

https://www.sciencedirect.com/science/article/pii/S096098222...

gonational 4 hours ago||
Use genetic engineering to extinct a species... what could go wrong?

Not to mention the many species of, e.g., birds, etc., that rely either heavily, or almost entirely, on mosquitoes, as a food source. One does not simply eradicate an entire species, through genetic sorcery, for the entire planet, without causing negative side effects.

This is just like cloud seeding. A few powerful idiots ruin it for everyone else, in the service of accomplishing a specific goal. We are likely experiencing major changes in the regional climates, as a result of cloud seeding. For example, right here in Idaho we are stealing water from clouds floating overhead, through a cloud seeding program primarily driven by Idaho Power. Do I benefit from this? Of course. We use the irrigation water and benefit from the cheap electricity rates. At what expense? Who knows. Somewhere east of us is likely getting royally screwed. As long as we have what we need here, though, who cares about anybody else or the rest of the planet's ecosystem, right?

The hilarious part, to me, is the fact that those who get excited by this idea (obliteration of entire species through genetic engineering) are the selfsame supposed champions of the climate when it comes to "GlObAl WaRmInG", asking for us to send our money to the Guberment to fix the problem. I guess it's not too surprising, since these people don't think for themselves; they are simply following with the TV told them to think.

vlod 7 hours ago||
Isn't there a knock on effect of removing them?

Does anything eat them as food? Wouldn't it be environmentally damaging to remove a source of food for X?

GuB-42 6 hours ago||
Mosquitoes control human populations, an invasive species. Removing mosquitoes will make humans proliferate, which is known to be environmentally damaging.

Joking aside, the consensus seems to be that the effect of removing disease-carrying mosquitoes (not all mosquitoes) from the environment is minor compared to how many lives it can save.

pigpop 7 hours ago|||
Aedes aegypti is an invasive species native to Africa so removing it from the environment everywhere else in the world that it has been spread to would benefit the local mosquito species which don't spread the same diseases and are less of a nuisance to humans.
fckgw 6 hours ago|||
Lots of animals eat mosquitos, but they really aren't the primary food source of any species, especially this particular type of mosquito. It would have a very minimal effect on food supply.
Tagbert 7 hours ago|||
There are still a lot of other mosquito species. removing just the few that carry human disease will not have a major impact on creatures that eat mosquitoes.
estearum 6 hours ago||
The mere existence of other things that we call mosquitos does not mean they are all interchangeable as a food source for the animals that eat them.

Is your level of knowledge on this just "there are other things called mosquitos ergo it's not a problem," or do you have deeper affirmative knowledge that the animals that eat these mosquitos also eat those other mosquitos, and that those other mosquitos can increase their population to replace the lost food source?

andrewflnr 2 hours ago||
Most things that eat mosquitoes are actually in the business of eating any flying insect that fits in their mouth. I'd be a bit more worried about, e.g. a species being the only pollinator for some plant, but that's pretty unlikely. Do the studies, sure, but don't expect any bombshells. And if aedes aegypti or any of the other big disease-causing mosquitoes had such a role, I'm pretty sure it would have already been found and trumpeted to the heavens.
estearum 2 hours ago||
The fact you can't even confidently say whether one of those species is a sole pollinator of a plant or not indicates that your comment is still just a stack of assumptions.
andrewflnr 1 hour ago||
And yours is still just fearmongering supposition, with, in my opinion, even less basis in reality. Go find some actual research on the ecological roles of aedes aegypti and anopheles if you want to get out of the loop. :)
estearum 1 hour ago||
I have done actual research on their roles! The answer is: "we don't really know."

That's called risk.

Pointing out risk is not "fearmongering" lmao

andrewflnr 1 hour ago||
Do we not know because people haven't gone looking, or because they did go looking and didn't find it? I'm guessing it's the latter, in which case it kinda strengthens the case that there probably isn't some critical role. These are some of the more-studied animals on the planet.

Pointing out risk is a kind of fearmongering when it's technically real but too small to be worth worrying about. Asteroid impact is a real risk too.

lefra 4 hours ago|||
In places where it's been living for hundreds of years, that's a legitimate concern.

In Europe though, where aedes aegypti didn't exist 20 years ago, it's probably the other way around: what did the introduction of this new species damage? (apart from making the summer unbearable outside if any of your neighbour isn't very strict with standing water elimination)

MisterMunchkin 4 hours ago|||
There isn’t, but why would I care?

A billion human lives, or some sad trout who have to eat fruit flies instead. For me, it’s an obvious choice.

I just can’t understand the level of smugness it must take to insist that we must force another billion people to die of horrible diseases like malaria, because you want the moral high ground. How do you even tell yourself that killing all those people is the moral high ground?

vlod 3 hours ago||
Your saying we do things that save human lives, irrespective of the outcome? Let's start by removing cars [0], that would save ~37K people.

Yeah, it gets a bit silly real fast. I've never been accused for forcing a billion to die, so thanks for that.

[0]: https://en.wikipedia.org/wiki/Motor_vehicle_fatality_rate_in...

BugsJustFindMe 3 hours ago||
> "Your saying we do things that save human lives, irrespective of the outcome?"

In fact, no, they did not say that. They said that the considered balance of the merits strongly favors eradicating the 2% of mosquito species that carry human diseases for someone who gives greater weight to the benefit of saving a billion human lives[0] than to the cost of some trout eating the thousands of other mosquito species instead.

[0] - 700 million contracted mosquito-borne illnesses each year worldwide. Death isn't the only consequence of significance.

larsiusprime 7 hours ago|||
I believe the argument is the dominant mosquito species are themselves invasive to the continent
estearum 6 hours ago||
"Invasive" is a made up human concept. The question is whether there are species that now rely on these as a food source. The entire natural world is a hodge-podge of "invasive" species coming from some nearby land, disrupting the ecosystem, then the ecosystem evolving around it – typically a gradual process over thousands of years.

If it took a couple hundred years for this species to proliferate, it's absolutely plausible that eradicating it in a few years will have surprising second- and third-order effects.

smt88 3 hours ago||
“Invasive” is a useful concept to describe species that spent millions (sometimes hundreds of millions) of years evolving in one environment and then moving to a new one in the last few thousand years.

Do you understand that time scales are important here?

There are also species that have invaded areas that are totally impossible for them to reach without seafaring or airfaring human civilizations to carry them.

All terms are made up. Some are useful and some are not. This one is useful.

estearum 2 hours ago||
The usefulness of the term to this conversation is as described: is this species systemically critical to its current ("invaded") ecosystem?

Merely calling it invasive does not answer that question, ergo it is not a useful term in this conversation.

And yes, timescales do matter. A species can become critical to its new ("invaded") ecosystem within a few hundred years such that removing it within a few years will cause catastrophe.

losvedir 2 hours ago|||
Are you proposing that it would be infinitely bad? That somehow extincting a few varieties of mosquitoes could cause the collapse of all life on earth?

I don't get the "but what if it's somewhat - not infinitely - bad" argument? The known good is so dramatically good that we'd need a shocking amount of unknown bad to have made it not worth it. But if I'm choosing between mosquitoes, and say... fish, frogs, and a variety of birds, yes, get rid of the mosquitoes.

vlod 1 hour ago||
I am merely suggesting we don't really understand the consequences and things may not be as simplistic that everyone thinks. i.e. kill "bad guy" mosquitos, save a billion people.

We start spraying crops so we can end world hunger (or just make more money) and screwing around with other things and now we're killing bees and other things. This will ultimately come to haunt us.

The death of all bees would count as infinitely bad (in terms of crop pollination) and we're doing a very good job in making that happen.

Tuna-Fish 7 hours ago|||
There are many mosquito species in competition for the same resources, only a few (iirc 10% in the US) of which sting humans and carry diseases. Wiping out the ones that attack people would allow other mosquitoes to take over the ecological niches.
andai 6 hours ago|||
The swallows love mosquitoes. When I get bit by mosquitoes I often joke I am feeding the birds.
vel0city 5 hours ago||
What's the ratio of frogs lives to human children spared from disease that's acceptable to you, assuming we had a clear answer?

If 20,000 humans weren't significantly harmed from disease because of this release, but 70,000 frogs faced starvation, which would you choose?

vlod 5 hours ago||
I was suggesting that it's rarely that simple.

If we lose those frogs, it most likely would cause a cascade across other species. There are lots of things that eat frogs.

BurningFrog 4 hours ago|||
I'm not a fan of "you never know" arguments.

They're only applied to thing we don't want to do.

In reality, it's always true that we don't fully know, so applying the argument always means "let's not do this".

vel0city 5 hours ago|||
I totally understand there's a massive amount of unknowns about this. Let's continue analyzing what's the right course of action as we go, and ensure we're taking that understanding into account of what we do in the future.

In the end, whose lives do you prioritize given the lack of information today, and the lives at risk today? Deciding to do nothing still costs lives, and potentially drives us further into the bad state area.

mbeavitt 7 hours ago||
Oh come on. Does anyone actually believe gene drives will work? This fundamentally goes against the principles of natural selection.

A gene which incurs a fitness cost will be purged from the population under selection!!

pigpop 6 hours ago||
Aedes aegypti are container breeders, you can totally eliminate them from an environment through diligent removal of standing water left in buckets, tires, pots, etc. This has been done before but the effort wasn't properly sustained so they've made a major comeback in disease prone areas. Killing a lot of them does have a substantial effect because they don't easily travel long distances by themselves so if the remaining resistant population is small enough it might just as easily end up dying out due to its breeding cycle being interrupted through other means. The part that should be criticized here is that any eradication campaign should also involve efforts to eliminate their breeding environments by removing junk and unattended containers that collect water.
chewbacha 6 hours ago|||
Sterile insect releases are a tool for suppressing populations and have been used for about a century. This is not really a new suppression technique but a novel way of producing the sterile insects.

It has been used to suppress screw worm in the United States for decades until the administration cut the funding.

These are almost always a temporary solution that need constant funding and seasonal releases to work. The populations will surge back as soon as it's stopped.

schiffern 7 hours ago|||
The idea is to hit the population with a cataclysm so sudden that it goes extinct before it can adapt. We can calculate mutation rates and reproduction dynamics, so we know how to predict whether this is likely or not.

If it's one-and-done, everywhere on Earth (eg smallpox), it can work. If it drags on for decades or isn't rolled out globally (eg malaria) then it won't work.

john_strinlai 7 hours ago|||
>Sustained releases cut a wild Aedes aegypti population in the Cayman Islands by 80 percent, and in a field trial in Juazeiro, Brazil by about 95 percent.
Tangurena2 2 hours ago|||
Female mosquitos mate once and only once. When they mate with a sterile male, none of her eggs will hatch.

Several insects are like this. In the species I'm familiar with, the male member breaks off inside the female locking all other males out.

Releasing sterile screwworms in Panama has been the main method of protecting US beef/cattle production from the insects spreading north out of South America.

https://www.pbs.org/newshour/nation/what-to-know-about-the-n...

mbeavitt 7 hours ago||||
Penicillin used to kill 100% of Staphylococcus aureus. My point still stands - even if a selective sweep takes out 99% of the population, they will recover.

This is at best a temporary solution.

qoez 7 hours ago|||
The remaining 5% and their adapted mutation will eventually repopulate the local population.
soulofmischief 6 hours ago|||
Humanity seems pretty good at driving animal populations to extinction. We're on our best run yet.
Noaidi 7 hours ago|||
Plus, the animals that eat those mosquitos will decline in the meantime...
bryanlarsen 7 hours ago|||
The gene gives a sizable advantage to mosquitoes that don't carry disease. Those mosquitoes will then take over the niche making it very difficult for disease carrying mosquitoes to come back.
christophilus 7 hours ago|||
I think you’re right. I’d want to pair this approach with introducing a replacement species that can hopefully out compete the one we’re eliminating. No idea what that looks like, though.
throwawayffffas 7 hours ago|||
That may very well mean the eradication of the population. Also we can do the gene drive repeatedly reintroducing the gene. Or modified genes.
twack 7 hours ago|||
Depends how fast the gene drive works. Natural Selection is slow.
mbeavitt 7 hours ago||
In a diverse population, the mutations that will drive the selection have in fact already happened. It doesn't matter how fast you move.
Tangurena2 1 hour ago||
> have in fact already happened

The US has been funding spraying of coca farms in South America. Roundup is one of the major herbicides. "Roundup Ready" crops are genetically modified to make them resistant to glyphosate. Samples of roundup resistant coca plants had been found in Colombia & Bolivia. It was thought that someone put a lot of effort into genetically modifying the plants, but it turns out that the samples were not GMO but rather mutants. Collaboration between coca growers spread the resistant plants.

https://en.wikipedia.org/wiki/Roundup_Ready

https://en.wikipedia.org/wiki/Boliviana_negra

https://web.archive.org/web/20050205025108/http://www.wired....

cmrx64 7 hours ago||
there are latches in designspace
rayiner 7 hours ago||
I hate all the glib wordplay that reframes a policy decision and turns it on its head to make it seem like a different kind of policy decision. Nobody is “choosing” to have mosquitos. Mosquitos exist naturally. Maybe we can undertake a large scale intervention in the environment and wipe them out, but it that’s different than “choosing” to have them. Just say what you mean.
SoftTalker 7 hours ago||
It's a choice to wipe them out or let them continue to exist. We were on our way to doing that using DDT until the unfortunate side-effects of that chemical were understood.
isolli 7 hours ago||
Hm, rather, as soon as (some) mosquitoes became resistant to DDT, eradication became a lost cause.
Tangurena2 1 hour ago|||
The pesticide levels built up in the insect predators of mosquitos (and other bugs) which tended to kill the predators and let the mosquito population explode.
SoftTalker 6 hours ago|||
The resistance was (perhaps counterintuitively) caused by overuse in agricultural applications.
isolli 6 hours ago|||
I agree. The precautionary principle applies to novel actions we take, not to leaving the status quo in place.
pigpop 7 hours ago|||
We are choosing to not undo the harm we caused by spreading Aedes aegypti all over the world in the first place.
Arodex 6 hours ago|||
If we are "choosing" to live with mosquitoes, then we also are "choosing" to let people starve, die of cancer, etc.

We could in one stroke take half of what multi-billionaires and quasi-trillionaires have hoarded. If they didn't have personal accountants, they wouldn't even notice it, as they have far more money than what they manage to burn through - and we would have the means to "choose" to solve real problems affecting hundreds of millions of people.

dctoedt 5 hours ago|||
> we also are "choosing" to let people starve, die of cancer, etc.

It's debatable whether taking half of billionaires' wealth would materially advance the efforts in those areas.

What seems far less debatable is the political consequences of the accummulation of so much wealth — coupled with essentially zero legal restrictions on the use of that wealth in the quest for (governmental) power.

isoprophlex 7 hours ago||
[flagged]
vel0city 5 hours ago|
I'm reminded of the horror movie Mimic, in which a genetically modified bugs are deployed to deal with a rampant cockroach population. Once the cockroaches are taken care of, the mutant bugs focus on the next disasterous infestation...humans!

https://en.wikipedia.org/wiki/Mimic_(film)

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