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Posted by dataking 12 hours ago

Early progress on accelerating drug development with Claude(www.anthropic.com)
217 points | 195 commentspage 3
blmarket 10 hours ago|
(sarcastic) Not too long until we see designer babies by Claude?
gherkinnn 2 hours ago||
With the rumours (?) around Musk very selective breeding, Grok may be first to have a go.
Maxion 2 hours ago||
Claude, make me a baby. Make no mistakes.
2001zhaozhao 11 hours ago||
I like how there's a giant "chapter picker" pinned at the top of the web page, but there are only two chapters and the second chapter is a tiny blob at the end of the article.
vatsachak 11 hours ago|
That's standard blog design though
rcr-anti 10 hours ago||
I work at a university, and part of the job is helping researchers with AI. Our bio and chem researchers are starting to despise Claude because it's been actively getting worse over the last months with increasingly aggressive guardrails. Many of them gave up because they feel they can't do anything useful with it anymore. There's a verified life sciences program, yeah. Is it an easy, transparent process capable of handling the hundreds at just our institution? Not even close. Best ad for open models though, thanks Anthropic!
jijji 5 hours ago|
exactly.
rao-v 10 hours ago||
I’m honestly a little surprised by the sparsity of examples? One example of improving an existing therapeutic (Generate Biomedicines), one example of speeding up an existing clever play in food allergies (Divergence Labs), one fairly generic lead optimization play, and then we get … Claude helped write better paperwork and documentation for Enveda?!

I know Anthropic are brilliant at knowing when to focus where, but I genuinely expected them to be talking about 3-5x more serious scaled up drug discovery plays at this stage.

Is this not a focus, or did the big plays not want to be part of a roundup post?

areoform 9 hours ago|
It's because these systems aren't as impactful in biology as folks who have never been in a lab would have you believe. Because believe it or not, you can't just go "Claude make me a drug!!"

Neural network driven drug candidate creation has been around since the 1980s. The blockbuster GLP-1 agonists were actually derived from the peptide in Gila monster venom by algorithmic search.

But you can't, and I can't emphasize this enough, just go "Claude make me a virus" and have it work. It just doesn't work that way. And the only reason why people think it does is because they haven't spent enough time in a lab, https://news.ycombinator.com/item?id=49620521

Don't get me wrong, this technology is worth fighting for because it will have incredible impact on the long time scale. But just not in ways they're talking about and expect. Nor the ways in which they're trying to dictate top down.

rao-v 9 hours ago||
Oh I’m aware - my point is it doesn’t even have “sorta” interesting attempts and pads with Claude for paperwork. OpenAI’s equivalent will have a bunch of cool sounding projects (which I agree will struggle to have the promised wins - with frontier general purpose models anyway)
Sarkie 11 hours ago||
New cocaine?
ChrisMarshallNY 11 hours ago||
We've had "research chemicals" for a couple of decades.

Some, do what it says on the tin.

Some...not so much.

The issue with any new chemical is full, comprehensive, regulated testing.

Dodgy folks aren't really so good, with that last part. They use their customers as guinea pigs.

bagacrap 6 hours ago||
What's wrong with the old cocaine?
inglor_cz 11 hours ago||
The point about finding problems in documented processes (Enveda: manufacturing and filings) is unexpected but interesting. One of our civilizational problems is that the sheer volume of documentation has slowly exceeded capabilities of humans to produce it reliably and without flaws.

Same applies to construction projects, BTW.

insane_dreamer 4 hours ago||
the bottleneck is and likely will always be the phase-2 and phase-3 trials.

I don't believe there's any shortage of _potential_ new medicines being developed, but very few get to the stage where they are proven to be both safe and effective.

If anything Claude might just increase the downstream bottlenecks.

Mistletoe 10 hours ago||
I’d love to read Derek Lowe from In The Pipeline eviscerate this.
jijji 5 hours ago|
if you try to ask Claude code any question related to molecular biology or biochemistry it will refuse to answer any of those questions.... the open models are the right step forward for any of this work. Same with computer security. The guardrails make the model unusable, and I would rather pay money to a more capable, open model that isnt going to put uuid fingerprints in my text and images it generates either btw.
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