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Posted by Anon84 3 days ago

Schizophrenia is the price we pay for minds poised near the edge of a cliff(www.psychiatrymargins.com)
255 points | 394 commentspage 2
drgo 2 days ago|
Is it possible that the pro-schizophrenia genes persist because they offer other (non-neurological) benefits, e.g., lower risk of cancer? Siblings of patients with schizophrenia are less likely to develop cancer, and in several studies these patients had lower risk of developing cancer despite higher prevalence of smoking.
lokar 2 days ago||
The benefit must be to reproduction. Cancer generally happens after peak reproductive years.
FollowingTheDao 2 days ago||
There’s no such thing as a “pro schizophrenia genes”. There are only genes that increase the risk of schizophrenia, and this is probably due to environmental variables.

Exchanging a risk for cancer for a risk of schizophrenia is not a win-win situation. You’re just switching one set of risk genes for another.

01HNNWZ0MV43FF 2 days ago|||
> There are only genes that increase the risk of schizophrenia

I think that's what GP was saying?

> You’re just switching one set of risk genes for another.

I think... that's what GP was saying?

FollowingTheDao 2 days ago||
>> You’re just switching one set of risk genes for another. > I think... that's what GP was saying?

If you are switching one low survival gene for another there is no net benefit.

mark-r 21 hours ago|||
It depends very much on the likelihood that the gene causes a disorder, and the deadliness of the disorder. Those two outcomes could be vastly different.
lazyasciiart 2 days ago|||
You're begging the question, They asked is there some unnoticed survival benefit.
ekaryotic 2 days ago|||
>Exchanging a risk for cancer for a risk of schizophrenia is not a win-win situation But it can be though. Consider a population that works with carcinogens like coal. due to capitalist class structures, they cannot leave their occupation, so a gene that would increase their survivability would be a great help.
dustbunny 2 days ago||
Schizophrenia is far more likely to prevent you from reproducing than cancer, because schizophrenia hits way earlier.
FollowingTheDao 2 days ago||
Yes, this is what I was going to comment, and adding that it was funny they used a coal miner as an example since my family side that has the mood disorders were all coal miners in central PA.
8bitsrule 2 days ago||
R.D. Laing was saying the same things 50 years ago.

" We must remember that we are living in an age in which the ground is shifting and the foundations are shaking. I cannot answer for other times and places. Perhaps it has always been so. We know it is true today. In these circumstances, we have all reason to be insecure. When the ultimate basis of our world is in question, we run to different holes in the ground; we scurry into roles, statuses, identities, interpersonal relations. We attempt to live in castles that can only be in the air, because there is no firm ground in the social cosmos on which to build."

"Sanity today appears to rest very largely on a capacity to adapt to the external world — the interpersonal world, and the realm of human collectivities. As this external human world is almost completely and totally estranged from the inner, any personal direct awareness of the inner world already entails grave risks."

boardwaalk 2 days ago||
Though it doesn’t mention it by name exactly, I think a related idea for systems that are optimized close to a point of phase change is “the edge of chaos”

https://en.m.wikipedia.org/wiki/Edge_of_chaos

gsf_emergency_2 2 days ago|
Trading stability for agility, basically?

https://www.humanfactors.lth.se/fileadmin/lusa/Sidney_Dekker...

zingababba 2 days ago||
Julian Jaynes' theory is always interesting to think about. I self-diagnosed myself as schizophrenic in my late teens and I still stand by my diagnosis 20 years later. I do believe it is a spectrum though and the degree to which one is schizophrenic is not static, and I don't think it's even necessarily a bad thing.
anonymars 2 days ago|
I assume you mean the bicameral mind / consciousness?
absurdo 2 days ago||
As expected a lot of the comments here are anecdotes. I’m assuming there exists a class of highly technical articles that get posted regularly that incite ancillary discussion, but no real contribution involving the article.

For me, I don’t like that this is about a mathematical model. I don’t want a mathematical model. I like the theory, and I think it’s interesting. I don’t need further digressions into a model. I want to see the real thing. Prove it, replicate it, codify it.

discoutdynamite 2 days ago||
For your consideration: the theory of "Positive Disintegration" developed by Kasimir Dabrowski does help to explain the capacity and reality of schizotypal disorders. The easiest way to explain it, is that human brain potential for "over-excitation" leads to personality development; this is natural and human. The stages of personality development are not guaranteed to succeed and proceed correctly. Most cases of schizophrenia may be a result of failed re-organization, or a failure to develop the final, executive, function. In cases of "arrested development," this process may be delayed till later in life. This is the so-called mid-life-crisis, which also can fail, and then you get adult onset schizophrenia. This is all emerging research thats usually locked up in foreign language journals. Almost no medicine to be sold here, AMA and APA are not interested...
HarHarVeryFunny 2 days ago||
Genetics is messy - as I understand it most genes don't code for a single thing, so assuming evolution is "selecting for schizophrenia" that only implies that there is an evolutionary benefit to some of the things controlled by the same gene(s) that control schizophrenia, that outweighs the disadvantage of schizophrenia.

Homosexuality is interesting from this perspective too - common enough that evolution has to be selecting for it, yet basically fatal to reproduction, so what are the benefits that evolution is selecting for? Is it advantageous to groups, or maybe the same genes confer an individual benefit to non-homosexuals?

KittenInABox 2 days ago||
> Homosexuality is interesting from this perspective too - common enough that evolution has to be selecting for it,

Are we sure this is the case? I think it's more like homosexuality isn't extremely selected against on a population level. Evolution doesn't really select for, more like evolution is a process in which least-viable-specimens are killed off for their environments. It could very well be that a small number of homosexual specimens are simply irrelevant to evolutionary fitness.

Fraterkes 2 days ago|||
For evolution to “select” for homosexuality, wouldn’t it have to be hereditary in large part? As far as I can tell, to the extent that theres any evidence for that the effect of genes on sexuality is kinda limited
HarHarVeryFunny 2 days ago||
Male vs female differences, including differences in typical sex-specific sexual attraction, are obviously genetic, even if we've yet to figure out all the specifics (where are the male's "curve detector" genes, etc).

Do men and women both have the coding for male/female attraction, with one typically disabled ? This perhaps seems most likely, in same way both sexes have nipples, etc. Without knowing exactly how this all works we can only speculate how male/female genes can combine to create same-sex attraction. Obviously it's not so simple as inheriting a gay gene from one of your parents!

throw4847285 2 days ago||
> Male vs female differences, including differences in typical sex-specific sexual attraction, are obviously genetic

Typical is putting in a lot of work in that sentence. I could rephrase it with the same truth content and make it much more ambiguous.

"Many phenotypical sexual differences in humans are obviously genetic. Some very common differences in sex-specific sexual attraction are likely genetic as well. For large swaths of sexual attraction, we have absolutely no evidence of a genetic link."

What's funny is that the one example you facetiously picked (a curve detector) is extremely culturally dependent. Trying to tie elements of human sexuality to evolutionary just so stories is usually pseudoscience. When we start isolating genes for the things that we think of as natural, if we ever do, I bet you $100 the mapping from our social experience of these traits to some kind genetic reality is muddled to the point of total detachment.

HarHarVeryFunny 2 days ago|||
> What's funny is that the one example you facetiously picked (a curve detector) is extremely culturally dependent.

Actually, it wasn't intended as facetious! I'd bet money that male attraction to females is indeed based on curve and jiggle detectors! If not this, then what - it has to be based on some (simple, perceptual) physical characteristics. I realize that female ideals vary a lot between cultures, and time periods, but the differences are more about things like fat percentage and distribution than the underlying characteristics that visibly differentiate men from women.

HarHarVeryFunny 2 days ago|||
> Some very common differences in sex-specific sexual attraction are likely genetic as well. For large swaths of sexual attraction, we have absolutely no evidence of a genetic link

Sure - it seems there may be a large degree of imprinting as well, but homosexuality does seem to be an important special case given that it typically means lack of descendants. Of course evolution is really about sub-populations and gene-pools, not individuals, and it seems there has to be some benefit at that level otherwise this trait would have been out-competed in the population.

skissane 1 day ago||
> but homosexuality does seem to be an important special case given that it typically means lack of descendants

For much of human history, that has been false. In many societies, there has been strong pressure to (heterosexually) marry, arranged marriages - with the result that most individuals with a homosexual orientation end up participating in heterosexual reproduction-so homosexuality is much less of an evolutionary disadvantage than you’d assume.

Modern Western society puts great emphasis on marrying for love, marrying on the basis of actual attraction rather than social pressure or political calculation, being “true to yourself” - and in such a society, a homosexual orientation does significantly reduce the odds of participation in classical heterosexual reproduction. But modern Western society isn’t normal in world-historical terms, what we consider “normal” is actually rather novel

renewiltord 2 days ago|||
The article's first paragraph has some alternative factors in selection

> Traditional evolutionary hypotheses, such as those invoking kin selection, mutation-selection balance, and evolutionary mismatch don’t quite explain this.

There's lots of explanations here but one that is often mentioned is "kin selection". If you increase evolutionary fitness of nephews, nieces, etc. There's many others, some of which apply here and others which don't.

no_wizard 2 days ago||
I always wondered if it was natures check on overpopulation. I know that is controversial to say, but it seems most fitting on its face
HarHarVeryFunny 2 days ago|||
My best guess it that there is a societal/group benefit in reducing aggression (maybe not unrelated to they way our closest DNA match, Bonobos, function).

I don't think we're at the point yet, and certainly not in last few million years of evolution, where overpopulation is an issue, and since evolution is all about (collectively) creating the largest next-generation population, this isn't the way I would expect to see increased competition for resources to play out.

missedthecue 2 days ago|||
Do rural populations have lower rates of homosexuals as a % of offspring? How would nature "know" we are overpopulated and bias towards homosexuals?
cageface 2 days ago||
Maybe this could explain why mental illness & creativity seem to be so closely related? Just as one example, James Joyce's daughter was schizophrenic.
kayodelycaon 2 days ago|
Mental illness and creativity are not closely related. There is correlation but mental illness is not required for creativity.

According to Wikipedia, creative people are 25% more likely to have a mental illness.

As for why so many bipolar people are famous, manic episodes can be very productive.

For myself, being bipolar has given me several lifetimes of perspective to inform my writing.

https://en.m.wikipedia.org/wiki/Creativity_and_mental_health

bumby 1 day ago|||
Not my area of expertise, so it should be taken with a boulder of salt, but there are other studies that seem to indicate a much higher correlation. Part of the problem may be that “creative” is a nebulous term. One Swedish study found that people with artistic backgrounds have a 1.9x likelihood of developing schizophrenia and 1.62x odds of developing bipolar disorder.

I suspect (with nothing to support it) that there is a range where people with mental illness are able to interpret the world differently than normies (and thus make connections that normies do not), but also a point where that perception gets so out of joint that they can no longer function in reality. So in the former case, it may help in creative pursuits, but the latter may hamper it.

andrewflnr 2 days ago|||
> Mental illness and creativity are not closely related. There is correlation

What do you think a correlation is if not a relationship? No one said it was "required".

kayodelycaon 2 days ago||
Yeah. I wasn’t clear. I do not believe that 1 and 1.25 is considered “close”.

There’s absolutely a correlation, enough to be causation. But it doesn’t make mental illness a primary factor in creativity in modern society.

PaulHoule 3 days ago|
Why does no-one dare say "schizotypy?"

https://en.wikipedia.org/wiki/Schizotypy

gfody 2 days ago||
many people hear voices and experience symptoms of schizophrenia while managing to keep their cool and thrive amongst the nerts. hearing-voices.org is a support network for such people
crawfordcomeaux 3 days ago||
It's dangerous to existing systems for people to become aware they're capable of creating/conjuring/channeling useful new voices in the mind to help learn different things. People get burned at the stake for that.
bad_haircut72 3 days ago|||
I've never ever had any symptoms of schizophrenia but the idea of trying to consciously encourage myself hearing voices is terrifying, Im sure I could send myself truly insane with probably not much effort.
WarOnPrivacy 2 days ago|||
> the idea of trying to consciously encourage myself hearing voices is terrifying,

This is not unreasonable.

It could be less awful if the voices were positive and not harsh and negative. Schizophrenics outside the US were found to have a more benign relationship with their voices.

    The striking difference was that while many of the African
    and Indian subjects registered predominantly positive experiences
    with their voices, not one American did. Rather, the U.S. subjects
    were more likely to report experiences as violent and hateful – and
    evidence of a sick condition. 
ref: https://news.stanford.edu/stories/2014/07/voices-culture-luh...
crawfordcomeaux 2 days ago||||
I once accidentally came up with another conscious voice in my head & we decided to govern through the 12 traditions of Codependents Anonymous. She also had specific qualities I'd chosen 3 weeks prior as qualities I chose to believe I could come to embody, so that was an interesting pointer to what's possible.

And as others have pointed out, it really depends what kind of programming you're carrying around. Feeling terrified of something isn't the issue...it's how you've trained to respond to terror that matters. If you lash out or avoid, yeah....don't cultivate multiple voices. If, instead, you're choosing to purge the addiction to violence & domination fairly rooted in American imperial colonial indoctrination, it's really quite something. I'm now working on bringing in 16 others as a way to better connect with different parts of the population and spread this and other blackness-embracing ways.

Hearing/seeing things that aren't there has historically for the majority of humanity's time on Earth not been an issue. We can get back to living in such ways, especially since doing so can be extremely helpful.

PaulHoule 2 days ago|||
My belief about is that the core of schizotypy and schizophrenia is

https://en.wikipedia.org/wiki/Thought_disorder

as did Eugen Bleuler. I have a friend who is schizophrenic whose speech hardly makes sense and she is always calling people on the phone and carrying on nonsensical conversations. Somehow the general public is hung up on ‘hearing voices’ but I have never once heard a voice but under stress I (schizotypal) did once spend about six months under the influence of a ‘system of delusions’ yet stayed mostly functional, kept working, and managed to avoid getting in serious trouble.

I think it is quite ordinary also for people to have a dialogue with an ‘invisible friend’ or believe that they ‘talk to God’ when they pray, the auditory hallucinations of schizophrenia seem to be something like you have a thought that you don’t think is your thought but somebody else talking, notably schizophrenics often believe that somebody is putting thoughts into them or taking thoughts out of them, see

https://www.theairloom.org/mindcontrol.php

DiscourseFan 2 days ago|||
It's like gang-stalking--its not that there's something being introduced, but rather that the subject sees relations that are not objective relations (like, for instance, the relation between temperature, pressure, and state change). Typically, however (and I can't imagine a case where this didn't happen), the relations are social in character--and since social relations are subjective to the extent that all the social world is not expressly a fact, it can be difficult to differentiate between an illusion and a reality: people imagine their partners are cheating on them, whether or not its true. And there are many things we do not know about the social world around us; but, statistically speaking, nobody has ever actually been gang-stalked.
overu589 2 days ago||
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andygeorge 2 days ago||
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dang 2 days ago|||
Please don't post unsubstantive comments.
overu589 1 day ago||
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overu589 2 days ago|||
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DiscourseFan 2 days ago|||
Modern medicine.
crawfordcomeaux 2 days ago|||
Hey there! Let's be friends! Too rare are there people speaking/writing past myopic American/western views here.
uniq7 2 days ago|||
That is very interesting. Excuse me if this question is too personal, but what do you mean by "system of delusions" exactly?
ivape 2 days ago||
A constant state of needing to do continuous reality testing. The GP almost lost a grip basically.
PaulHoule 2 days ago|||
Dangerous to the autism-industrial complex and as well as the addictive stimulant industry.
WarOnPrivacy 2 days ago|||
> addictive stimulant industry.

Whom I thank every day for repairing my retention processes, just enough that lessons become learning.

astrange 2 days ago||||
Stimulants reduce addictive behaviors in ADHD patients.

https://www.additudemag.com/adhd-and-substance-abuse-stimula...

They're also less habit forming than the non-stimulant drugs; I'm taking a non-stimulant right now (Intuniv) that you can't safely quit without tapering off for weeks.

The combination is good enough that I lost my caffeine addiction. Of course that's a relatively mild one.

amanaplanacanal 2 days ago|||
Is this supposed to be some kind of diss for adhd stimulant therapy?
PaulHoule 2 days ago||
Gotta a friend who’s 52 and has all his teeth rot out 10 years ago. He goes to Wegmans every month and comes back with a pill bottle the size of a small trashcan. He says he could get nothing done without out but I don’t see him getting anything done. Wouldn’t be surprised if will fall and break his hip 20 years early.

I’ve seen plenty of those pills get diverted with outcomes like somebody stays up for 4 days and gets hospitalized so, yeah, I want to diss ADHD medication. It is clear it helps in the short term, not so clear if it helps in the long term.

WarOnPrivacy 2 days ago|||
> Gotta a friend who’s 52 and has all his teeth rot out 10 years ago.

FTR, meth mouth has no overlap with ADHD meds. I specifically looked into this, way back when.

> He goes to Wegmans every month and comes back with a pill bottle the size of a small trashcan.

If he took that many ADHD meds he'd be dead on day one. Three tabs/day is a heavy dose.

fragmede 2 days ago|||
How scientific.
PaulHoule 2 days ago||
https://pubmed.ncbi.nlm.nih.gov/35091797/
WarOnPrivacy 2 days ago||
Even that very limited study didn't link stim use to poor teeth - at all. As far as study went, this was it.

    • Stimulant ADHD medication use in adults is associated with decreased bone
     mineral in the skull and thoracic spine.

    • No other areas of axial or appendicular skeleton showed significant
    differences.

    • There was no dose-response effect between stimulant medication use and
    bone mineral density.

    • The overall effect of stimulant medications on adult
    bone health is unclear. 
ref: https://pmc.ncbi.nlm.nih.gov/articles/PMC9062265/
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