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Posted by bilsbie 18 hours ago

How to sequence your own DNA at home(bradleywoolf.com)
352 points | 136 commentspage 2
samuell 8 hours ago|
Is this the same guy behind https://iwantosequencemygenomeathome.com/ ?

[Edit: Apparently no. That link is by Seth Howes, who also shared the OP post though: https://x.com/SethSHowes/status/2074231119730430203 ]

kriro 8 hours ago||
It seems a bit odd to me to have a home lab for the sequencing and then feed it to a cloud LLM. I would have thought the point of the home lab is privacy.
PunchTornado 8 hours ago|
Not really. It is to learn.
sublimefire 6 hours ago||
It might make even more sense once we get to the point of a wider use of encoding the data into dna. For now we have these few commercial players in the field that cad do it (eg look up dna microfactory for storage archiving), IIRC genomika was saying they can do an MB for a 100-200eur.
felooboolooomba 10 hours ago||
How can I know if the the results I get are real or just some garbage?
m0do1 10 hours ago||
via comparison to other nucleotide sequences. This is called sequence alignment: https://en.wikipedia.org/wiki/Sequence_alignment
fragmede 10 hours ago||
Run it multiple times, and then get professionals in on it as well, and then compare.
bluerooibos 7 hours ago||
> Oxford Nanopore Technologies MinION ($7.5k)

Hmm, I'll come back in a few years when things have become cheaper.

jebus989 3 hours ago|
It's been around for a decade and was $1k in early access, so don't hold your breath.
purpleidea 14 hours ago||
I like the privacy conscious aspects. Apart from the obvious issue of "run it through Claude" how many of those referenced analysis tools are entirely open source or at least run locally? Would have liked to see that in the article.
ggirelli 12 hours ago|
At a quick glance, they all seem to have published their source code and they do run locally.
giantg2 3 hours ago||
If the sequencer was 10x cheaper then I might do it.
thomasfromcdnjs 12 hours ago||
I'm waiting for someone to make an open source gene sharing platform to rival ancestry etc in the future.

There must be some cool way to share enough structure with some cryptography to share parts of your dna to find relatives etc

KashifNY 13 hours ago||
Bringing everything to your doorstep and everything at your feet and everything near your fingertips is just what all industries are trying to accomplice. The cartoon Animation Wall-E has scenes in it where they show obese humans doing everything through a screen though notice their legs and feet and it's as if they've mutated to a point where they aren't able to walk anymore and all their transport is through a hovering chair cum bed.
mirmor23 12 hours ago|
I watched wall-e in theater, and when that scene came on, i remember muttering 'what bs'; since then, i recall that scene every time i see a situation of 'convenience at all costs'; metaphorically they were pretty accurate even after discounting ozempic influence;
brikym 11 hours ago|
With such cheap costs every city should be sequencing dog turds and sending out big fines. The pay back would be very quick.
podocarp 7 hours ago||
I think cameras or even just a reporting hotline would be easier. The problem is lack of motivation I think rather than a money thing.
colechristensen 11 hours ago||
It's quite a bit more difficult with poop. A rather large proportion of the DNA in poop isn't from the creature that pooped it. (mostly bacteria)
kriro 8 hours ago||
And you'd need the DNA of all dogs to boot (unless they are already somehow stored when a dog is registered). But generally speaking, I do like the idea. Also for horse poop which is pretty common on roads here in the countryside.
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