Posted by jnord 16 hours ago
To me, these are clearly not independent paths, but rather the branching of proto-life into two of the great kingdoms of life. It’s a stretch to call this two origins rather than a branching.
Then a couple billion years later, one of em ate the other, and rather than destroy it, they both started a symbiotic relationship, and we were off to the eukaryotic race. This is all the same web of life. Not two independent streams.
It's kind of interesting that there's parasites that arguably don't meet this definition either. Looking it up: Chlamydia can't reproduce independently; relies on its host's metabolism. Microsporidia can't make ATP on its own. Are these "life"?
Somewhere in there is a transition. But it’s poorly defined, and so the argument can be there was a bifurcation of sorts.
The origin of life is as romantic as I’d hoped.
Well, sure. For it to ever be possible to say "life arose more than once," one must decide where the boundary between life and non-life is. After all, every precursor of life arose all at once, in the Big Bang!
Its stages, but it’s a bit hard to say “early stage was a single origin, then we count each bifurcated radiation as a separate start point”. Why not call it convergent evolution, which it would be, over a very long time period?
That is, what sustains today’s life prevents new proto-life for forming. You need to have the fancy gadgets life has today to continue to survive and replicate on Earth.
Note though, it was other life forms that contributed to the great oxygenation event, too. This is all a continuous web.
Do you think complex life could develop (perhaps by moving backwards) in a way that they rely on an anaerobic metal-rich environment?
I guess the oxidation event maybe was necessary for life to develop enzymes (since there wasn't sufficient evolutionary advantage for it to develop in an anaerobic environment?) but maybe something could go backwards? I'm just curious if there might be advantages for live in that sort of environment.
> Just curious, are there lifeforms today that rely on these metals to live in anaerobic environments? Maybe the hydrothermal vents that are talked about?
There are actually quite a few environments on Earth that are time capsules / have little ship bottles of very different life inside of them. For example, the Movile cave, https://en.wikipedia.org/wiki/Movile_Cave
Life in the cave has been separated from the outside for the past 5.5 million years and it is based completely on chemosynthesis. Due to its extreme environment, access to Movile Cave is strictly controlled, and a limited number of researchers have permission to study its conditions.
[1] https://en.wikipedia.org/wiki/Dissimilatory_metal-reducing_m...
[2] https://en.wikipedia.org/wiki/Sulfate-reducing_microorganism
What proto life did, it seems, was completely depend on metal surfaces to speed up some reactions. But that’s messy. The same metal can’t distinguish different components, so there would be competition for these surfaces, even within the same “cell”. That’s not ideal.
Enzymes are much more specific. You can actually sequester different reactions. And once you have life that’s learned to do that, it will out compete any proto life like matter that may access such environments.
Anaerobic microbes have enzymes also. So don’t think that reducing conditions mean no enzymes. It’s merely that in reduced conditions, you have metal that’s not oxidized available for early life -like goo to make use of. Over time, once this life learns to make newer and newer enzymes, the need to be metal dependent went away.
Somewhat separately, you also had some of this lineage learn to photosynthesize, and that lead to bulk oxygen in the atmosphere, and that was initially catastrophic, then highly beneficial because oxygen based chemistry is way more energetic than anaerobic chemistry.
It would be wrong to think of either condition as “better” though. They’re different. They force different tradeoffs. And both demand fine balance and dependence on the environment, eventually.
The surfaces of clay particles in these lakes have been dubbed "the primordial sandwich".
The early protocells were 'alive', they were self-replicating, but they required nutrients and metabolic processes that only existed near mineral surfaces and would starve if they drifted away. They had to evolve new enzymes to become 'free-living'.
So it looks like the LUCA was one of these early protocells with an incomplete metabolism.
It's possible OoL requires some exponentially unlikely step. We wouldn't realize that because of observer selection: had the step not occurred, we wouldn't be here to be thinking about it. There's a huge complexity gap between the stuff produced in OoL experiments and the simplest known life.
It's also possible OoL requires conditions that no longer exist on Earth, or that only existed in the early Earth (or wherever life got started in the Solar System). For example, if it depended on the existence of short lived radioactive isotopes or free ammonia.
Indeed, all species branch out from that one universal common ancestor that was the first free living successful cell.
Put another way: forming life isn’t easy at all. And once it forms it changes conditions to suit its continuation, not to allow new life to form.
Probably this. How would we know what such 'proto-life' (perhaps even just some self-replicating soup of chemicals, no cell wall) would look like? Where to find it? How rare its occurence? Etc etc.
Scientists might not even recognise it if happened right in front of them.
I'd put my money on coming up with a more general definition of "life", and then looking for short(est) pathways from "soup of random chemicals" to "something in there that replicates (parts of) itself".
Doesn't need to look like life as we know it, as long as some elements of "self-organising structures, something being replicated" are there.
And life may have arisen from a very low probability set of circumstances ... there's no reason to expect it to be happening all the time.
The fact that it doesn't is a pretty simple solution to the Fermi Paradox.
Anything that's so agreeable to abiogenesis that life might spontaneously manifest, is actually pretty tasty for things already alive. They swoop in and eat it before it gets started. So, I suspect that even what the article says isn't that they both arose in the same place, but in different places separated by distance, time, and/or environmental barriers.
* https://en.wikipedia.org/wiki/Great_Oxidation_Event
one of my absolute favorite PBS Space Time on the subject
What makes that argument extremely weak is analogies with contemporary obviously living animals.
For example, humans are not alive, because we get 100% of our vitamin D ascorbic acid by scavenging from the environment, along with a handful of other animals that presumably evolved in an extremely vitamin C rich environment. If any animal, including humans, ever evolve a new ability to internally synthesize vitamin C from glucose like every other animal, then given that there were non-synthesizer animals in their ancestry who we arbitrarily define as not-alive aka dead, then we could say that life evolved twice.
Note that humans could be defined as dead because we can't synthesize our own oxygen and have to scavenge 100% of it from the environment using lungs and so forth.
If you pencil whip the English language hard enough, anything with lungs or stomachs is not alive. A similar line of argument would lead to all saprophytes not being alive, which is pretty ridiculous. Wood eating mushrooms are not alive because they rely on the environment to provide all their wood dietary needs. Yeah OK whatever.
That wouldn’t have been the case in these early beings, that were simply not capable of doing anything without these metals.
Anyway, it does provide a nice reason that bacterial and archaeal cell membranes are different.
Should be "Life left mineral substrate at least twice" or some such. The research is interesting, but they're playing word games in the telling of it by saying the most recent common ancestor of all life wasn't alive (because it was dependent on a mineral surface), but two of it's children gave rise to lineages that were.
> “When we react phosphite, a form of phosphorus that naturally occurs in hydrothermal vents, with organic compounds, we get metabolic phosphorylation reactions overnight in water. Phosphite and palladium replace ATP and enzymes; it’s amazing, and it makes early evolution a lot easier to grasp” says Schlikker.
As far as I know, there are no palladium enzymes ... checks ... ok, no _natural_ ones (that we know of). Which is interesting, as other enzymes in metabolism that use metals seem to have 'adopted' the metal(s) as a cofactor - like nickel, iron, molybdenum, even vanadium in at least one case.
I wonder if LUCA was not a single cell, but many different populations in different hydrothermal vents, exchanging genetic material wrapped by accident in the remains of the cell membranes as the host cells die and are ejected from their vents.
Perhaps the missing post-LUCA metabolic enzymes evolved by accident from proteins recruited simply to concentrate the required metal ions that are scarcer and ever more diluted the farther from the black smokers you get. Free living was merely a happy bonus effect.
I assume that the difference here, is that it went completely to zero, before restarting. The other times, there was a bit clinging on, that seeded the restart.