Posted by bohaska 7 hours ago
https://d.lib.msu.edu/etd/51312
Indicates 2mg and 5mg were given along with the placebo. While these are common dosages available in the US, these are higher dosages than recommended by at least some sleep experts. The thesis doesn't seem to differentiate between the dosages when evaluating cognitive processes.
Now I want to evaluate my sleep stack against morning cognition.
I apologize for not reading the full study before submitting it on Hacker News and for the misleading headline on the frontpage given the context of the dosages used, I really should have noticed that the link only contained an abstract.
I would be groggy a few hours after taking the pill but not in the morning.
https://store.usp.org/product/1380105?srsltid=AfmBOop0oZFH9S...
But I accidentally ran this test on myself recently and didn’t realise until I got home and found my full cup on the bench.
It was disturbing to know how much I need it.
4 is almost universally too much..
3 is the most I’ve ever recommended.
More than enough.
Personal experience: I have mild insomnia* and I sometimes take melatonin. It generally does help, but I can be groggy in the morning, if I took it too late in the evening. Happens sometimes. But for me, it's so much better to be sometimes a bit groggy for a short while, compared to being completely exhausted from sleep deprivation all day.
*I was a startup founder for 10 years and practically did not sleep during that time. Even years after that life, it feels like my body is not responding to melatonin that much. Or my body is not secreting enough itself. Who knows.
This is from the first paragraph in the abstract:
> Exogenous melatonin has been shown to improve sleep in individuals with sleep disorders, such as insomnia and delayed sleep phase disorder. However, research on the effect of exogenous melatonin on sleep in healthy young adults is limited.
Regarding "sleep more to be more efficient"; Hard to say without visiting a parallel universe. But in this specific case it was really about having enough hours in a day. Most of the work did not require me at my sharpest. If I was in the same situation today, Claude would be doing these menial things for me and I'd sleep more. But we didn't have Claude then.
It was a tech startup that I wanted to build without any outside money. With investments of course I'd just hire more people. I had luck and perseverance, and everything turned out great. I had 100% ownership and sold it for private equity. Now I only work because I like solving tricky problems, and not working gets incredibly boring after a while.
I certainly did and struggle with both sleep and stress induced anxiety, 9 years after my founder burnout.
My mornings have always been impaired, going back to pre-school. Meds don't make my mornings any worse than my baseline.
Glycine takes some getting used to, as you will have crazy intense dreams at first. But it is a very safe supplement to take even in large doses.
I always had huge insomnia issues after a physically intensive days after workouts. The stack I settled on solved it. A heavy day just needs a bit more magnesium and quite a bit more glycine.