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Posted by emigre 3 hours ago

Human brain is two separate organs, Stanford Medicine-led research finds(med.stanford.edu)
173 points | 56 comments
itvision 2 hours ago|
What a way to oversell the discovery.

The reality is:

    * Different brain regions have different functions: ancient knowledge.
    * Different regions contain distinct cell types and molecular programs: also well established.
    * Anterior and posterior brain structures may trace back to fundamentally separate progenitor lineages that were independently specified very early in evolution and development: that's the interesting new result.
The headline should have been: "Human forebrain and hindbrain arise from distinct embryonic progenitor lineages" - not that we have "two organs" in the brain.
sandeepkd 1 hour ago||
Though I agree with the detailed differentiation, still for the headline purpose a generic one that resonates with people easily isn't a bad choice
jibal 1 hour ago|||
Lying is always a bad choice. The paper in Nature says

"Hence, we postulate the brain is a composite organ emanating from two lineage-restricted progenitors; these dual progenitors may be evolutionarily conserved across 550 million years from hemichordates to mammals."

KajMagnus 39 minutes ago|||
If they had written instead:

"Human brain was two separate organs"

Then, both attention grabbig and true?

bryanrasmussen 5 minutes ago|||
Human Brain Evolved From Two Separate Organs.
b112 16 minutes ago|||
Probably not, because by the time hominids were a thing, it was one.

(if I'm reading parent poster correctly)

nextaccountic 14 minutes ago|||
Are there other composite organs?
lucideer 1 hour ago|||
Given the parallel example cited in the article of jellyfish having two spatially separate organs, & the subsequent speculation that our own ancestors could also have had spacially separate anterior & posterior masses, the title doesn't really seem unreasonable in its hyperbole.

While it might not be perfectly accurate it's hardly misleading.

stymaar 1 hour ago||
I found the title confusing, at the very least because it can be argued that the two brain hemispheres are two organs already, as they operate independently when severed from each other.
nkmnz 47 minutes ago|||
I'm pretty sure the third thesis has been taught in my university physiology classes 20 years ago, too.
popalchemist 55 minutes ago|||
If the two parts arise independently, then the headline may be a bit clunky but it is technically correct.
Mistletoe 57 minutes ago|||
It’s the PR arm of a university, they always do this.
bell-cot 1 minute ago||
Pretty much, and they've less shame than a British tabloid in how far they go.

When submitting, one can try to replace the title with something honest. HN does not favor that, mostly due to submitters having their own biases.

The best tactic is finding a higher quality article on the subject, to submit instead. That's uncertain, takes time, and may run into paywall issues.

t-writescode 1 hour ago|||
I mean, I learned a bunch of neat new stuff, so I’m excited!
akoboldfrying 12 minutes ago|||
Oh, I think we could crank that headline even harder while still keeping one toe on the truth. For example:

"Elon Musk's Brain is Two Separate Organs"

lovich 1 hour ago||
Additionally the only images in the linked article are also face pics of the researchers instead of anything on the information about said research.

I want to trust science and dislike anti vaxxers but it’s difficult to argue against them when researchers act like the caricature they are mocked as.

Self aggrandizing articles with misleading headlines is giving me 2 triggers for not trusting the content.

bethekind 2 hours ago||
> They identified two different brain progenitor cells. One, which expresses a gene called Otx2, is destined to become the forebrain and midbrain. The other, which expresses a gene called Gbx2, is committed to forming the hindbrain. They showed that these two cell populations never overlap; they are mutually exclusive from the earliest stages of development.

Very cool. Never thought the brain could have two completely different ancestors

kazinator 2 hours ago||
Fun fact: the hindbrain progenitor cell is shaped like a little lizard.
akk0 33 minutes ago||
The lizard brain, not because it resembles the brain of a lizard, but because it's made up of a trillion tiny lizards
trhway 2 hours ago||
and from another post on the front page right now https://news.ycombinator.com/item?id=49735541 :

"Nervous systems are typically defined as networks of neurons that communicate across synapses. But Burkhardt’s lab found something unique in ctenophores: Beneath the animal’s outer surface is a nerve net (pink mesh in this 3D reconstruction) whose neurons are connected by continuous cytoplasm — but with no synapses between them. “I don’t think any other animal has a nervous system like that,” Burkhardt said. Because ctenophores are one of the earliest branches of the animal family tree, the finding indicates that evolution may have crafted nervous systems twice: in ctenophores, and separately in jellyfish and all other animals."

ozim 1 hour ago||
Funny thing when reading that is as a human I read „crafted nervous system twice” like it would be done over a week or two.

We fail to imagine how much time takes to „craft a nervous system”.

Super scary how small are we in big scheme of things.

cmrx64 1 hour ago|||
https://learn.genetics.utah.edu/content/senses/eye/

at one point I learned that it would only take a few hundred thousand years to evolve an eye, and time felt much deeper.

stymaar 1 hour ago|||
I think the fact that the sentence says we share the nervous system with jellyfish gives a good indication of that.
ksenzee 1 hour ago||
The really exciting thing in this article is that this research led them to a new technique for growing brain stem cells in vitro, which has been very difficult until now. If that isn't being oversold, it's big news. That's going to make future research into diseases like ALS a lot easier.
meindnoch 42 minutes ago||
Fun fact: 80% of the brain's neurons are in the cerebellum, not the cortex.

In other words: only <20% of pur neuron budget goes to higher cognition (thinking, language, seeing, hearing). 80% is spent on motor skills.

k310 2 hours ago||
bioRxiv preprint July 2025 [0]

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

[0] https://www.biorxiv.org/content/10.1101/2025.07.02.662771v2

PDF is free to download.

msephton 2 hours ago||
Related https://www.newscientist.com/article/2589739-our-brain-evolv... https://news.ycombinator.com/item?id=49755533
jabagawee 1 hour ago||
> The new research finding shows that the human brain consists of two ancient nervous systems cleverly packaged together — a more primitive part that regulates our hearts’ beating, our breathing and other functions, and another that makes us distinctly human, capable of poetry, mathematics and wondering about our own origins.

I'm not sure the actual article in Nature Neuroscience [1] actually says that. I remember "Your Brain Is Not an Onion With a Tiny Reptile Inside" [2] from a few years ago, but I'm not sure where the dissonance comes from: my own misunderstanding, the press release using a popular but flawed model to communicate with laymen, or these two articles being in direct contradiction with each other?

[1]: https://www.nature.com/articles/s41593-026-02433-7 [2]: https://journals.sagepub.com/doi/10.1177/0963721420917687

zargon 27 minutes ago||
"Your Brain Is Not an Onion With a Tiny Reptile Inside" is a really stupid and pretentious article arguing against a straw man.
dr_dshiv 50 minutes ago||
[2] is an annoying pedantic article that illustrates little beyond a misconception of a misconception.
Perenti 31 minutes ago||
All the comments I see are about is it two organs, or a composite organ.

Surely the interesting thing is the ability to grow hindbrain cells in vitreo. That's what's potentially going to lead to the cure of lots of things, not whether 1=2.

fooker 20 minutes ago||
So, what we colloquially call 'reptile brain' turns out to be somewhat accurate.
trocado 53 minutes ago|
What is the difference between saying that the brain is two organs, as in the title, or a "composite organ" as in the actual paper? What makes an organ a single autonomous organ?
samus 3 minutes ago|
[delayed]
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